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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
A recombinant His-tagged protein fragment within the extracellular region of human DC-SIGN.
- 亚型:
mouse IgG1
- 形态:
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.02% sodium azide. Antibody was purified by Protein-A affinity chromatography.
- 保存条件:
Store at 4°C.
- 克隆性:
单克隆
- 标记物:
见下方详细说明
- 适应物种:
H
- 保质期:
1-2年
- 抗原来源:
A recombinant His-tagged protein fragment within the extracellular region of human DC-SIGN.
- 目录编号:
253248
- 级别:
超纯
- 库存:
大量
- 供应商:
Abbiotec
- 宿主:
Mouse
- 应用范围:
E, WB, IHC
- 浓度:
见详细说明信息
- 靶点:
DC-SIGN (8B6)
- 抗体英文名:
DC-SIGN (8B6) Antibody
- 抗体名:
DC-SIGN (8B6) Antibody
- 规格:
0.1 mg
DC-SIGN (8B6) Antibody产品详细介绍:
| 产品名称: | DC-SIGN (8B6) Antibody |
| 说明书: | 【点击查看详细说明及参考图片】 |
| 货号: | 253248 |
| 规格: | 0.1 mg |
| 产品描述: | Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN (3). A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum. |
| 克隆类型: | Mouse Monoclonal Antibody |
| 亚型: | mouse IgG1 |
| 免疫原: | A recombinant His-tagged protein fragment within the extracellular region of human DC-SIGN. |
| 适用物种: | H |
| 应用范围: | E, WB, IHC |
| 应用说明: | E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 别名: | DC-SIGN; Dendritic cell-specific ICAM-3-grabbing nonintegrin 1 |
| 形态: | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.02% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存条件: | Store at 4°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献: |
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文献和实验/aptrix/upp00919.nsf/(FileDownload)?OpenAgent&docid=B9EC173AF3C88B18C1256EB400417CCF&file=Proc.PlusTechMan.pdf 亲和层析原理和方法(160页) http://www5.amershambiosciences.com/aptrix/upp00919.nsf/(FileDownload)?OpenAgent&docid=91D3DF5DE303E8B6C1256EB400417F34&file
不同,可逃避单一抗感染免疫。布氏锥虫和东非锥虫的表面糖蛋白基因数量多达l 000种以上,导致抗原的高度变异。溶组织内阿米巴、血吸虫幼虫和锥虫等还可失去其原有表面抗原,逃避免疫效应攻击。 ④抑制抗感染免疫效应:肺内血吸虫表面表达DAF样蛋白,抑制补体激活效应;枯氏锥虫合成DAF样膜糖蛋白,抑制补体活化;利什曼原虫前鞭毛体破坏补体MAC,逃避溶菌作用;刚地弓形虫抑制吞噬体与溶酶体的融合,枯氏锥虫溶解吞噬体膜逸人胞质等均可逃避Me的杀灭作用。某些蠕虫分泌胞外酶降解结合在虫体膜表面的抗体
结合介导感染。而ACE2是局部高血压蛋白酶原-血管紧张素系统的负调控蛋白,可保护肺泡的实验性损伤。SARS-CoV感染可下调肺部ACE2水平,加剧肺损伤。SRAS也可能通过另一细胞受体C-lectin-CD209(DC-SIGN)和CD209L(DC-SIGNR)感染免疫细胞,IX;可能参与了病毒感染与抗原提呈过程。 固有免疫不足以清除病毒感染,而在抗SARS-CoY适应性免疫诱导过程中,发现感染第10日患者体内病毒达到高峰,15d后病毒逐渐下降,21 d可测特异性IgM
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