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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Purified recombinant fragment of human SMAD6 expressed in E. coli. <br> <br>
- 亚型:
Mouse IgG1
- 形态:
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
- 保存条件:
Store at -20°C
- 克隆性:
单克隆
- 标记物:
见下方详细说明
- 适应物种:
H
- 保质期:
1-2年
- 抗原来源:
Purified recombinant fragment of human SMAD6 expressed in E. coli. <br> <br>
- 目录编号:
253056
- 级别:
超纯
- 库存:
大量
- 供应商:
Abbiotec
- 宿主:
Mouse
- 应用范围:
WB
- 浓度:
见详细说明信息
- 靶点:
SMAD6 (5H3)
- 抗体英文名:
SMAD6 (5H3) Antibody
- 抗体名:
SMAD6 (5H3) Antibody
- 规格:
0.1 ml
SMAD6 (5H3) Antibody产品详细介绍:
| 产品名称: | SMAD6 (5H3) Antibody |
| 说明书: | 【点击查看详细说明及参考图片】 |
| 货号: | 253056 |
| 规格: | 0.1 ml |
| 产品描述: | SMAD6 (Mothers against decapentaplegic homolog 6) protein is an antagonist of signaling by TGF-beta type 1 receptor superfamily members. It has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. SMAD6 is ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. |
| 克隆类型: | Mouse Monoclonal Antibody |
| 亚型: | Mouse IgG1 |
| 免疫原: | Purified recombinant fragment of human SMAD6 expressed in E. coli. |
| 适用物种: | H |
| 应用范围: | WB |
| 应用说明: | WB: 1:500-1:2000; |
| 别名: | Mothers against decapentaplegic homolog 6; MAD homolog 6; Mothers against DPP homolog 6; SMAD family member 6; SMAD 6; Smad6; hSMAD6; MADH6; SMAD6 |
| 形态: | Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存条件: | Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 参考文献: |
ABBIOTEC产品提供质量保证,提供完善的售后和技术支持,ABBIOTEC产品正品包装:
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文献和实验相关实验
胰腺上皮内瘤变和胰腺癌组织中TGF-f3/Smad信号通路相关蛋白表达
转化生长因子(TGF)-13/Smads信号传导通路是由TGF-B超家族、TGF-B受体,Smad蛋白家族及其核内转录调节因子组成的肿瘤抑制通路。通路中任一元件的异常都可以引起TGF.13/Smads信号传导紊乱,从而导致肿瘤的发生¨ 。研究表明,半数以上的胰腺癌都有TGF-13/Smads信号传导异常,其发生机制主要包括Smad基因家族突变(主要为Smad4)和表达异常(Smad6,7),也涉及TGF-B超家族及其受体的改变 J。胰腺
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SMAD6 (5H3) Antibody_SMAD6 (5H3)抗体
¥3000 - 3999









