CLOCK (Circadian locomoter output cycles protein kaput) heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. CLOCK activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. CLOCK has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. CLOCK acetylates primarily histones H3 and H4.
克隆类型:
Mouse Monoclonal Antibody
亚型:
Mouse IgG1
免疫原:
Purified recombinant fragment of human CLOCK expressed in E. coli.
适用物种:
H
应用范围:
WB, FC
应用说明:
WB: 1:500-1:2000;FC: 1:200-1:400;
别名:
Circadian locomoter output cycles protein kaput; hCLOCK; Class E basic helix-loop-helix protein 8; CLOCK; BHLHE8; KIAA0334
形态:
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
保存条件:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.