- ￥3000 - 3999
- Abbiotec
- 美国
- 252878
- 2026年05月22日
- WB, IF
- Mouse
- H
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Purified recombinant extracellular fragment of human TrkA(aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
- 亚型：
Mouse IgG1
- 形态：
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
- 保存条件：
Store at -20°C
- 克隆性：
单克隆
- 标记物：
见下方详细说明
- 适应物种：
H
- 保质期：
1-2年
- 抗原来源：
Purified recombinant extracellular fragment of human TrkA(aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
- 目录编号：
252878
- 级别：
超纯
- 库存：
大量
- 供应商：
Abbiotec
- 宿主：
Mouse
- 应用范围：
WB, IF
- 浓度：
见详细说明信息
- 靶点：
TrkA (6B2)
- 抗体英文名：
TrkA (6B2) Antibody
- 抗体名：
TrkA (6B2) Antibody
- 规格：
0.1 ml
TrkA (6B2) Antibody产品详细介绍：
| 产品名称： | TrkA (6B2) Antibody |
| 说明书： | 【点击查看详细说明及参考图片】 |
| 货号： | 252878 |
| 规格： | 0.1 ml |
| 产品描述： | TrkA is a 140-kDa cell surface receptor (gp140) expressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of TrkA in neural cell lines and embryonic dorsal root ganglia. TrkA is a receptor of high-affinity for NGF, neurotrophin-3 and neurotrophin 4/5 but not BDNF. TrkA exists in a dynamic equilibrim between monomeric (low affinity) and dimeric (high affinity) structures. TrkA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Defects in TrkA are a cause of congenital insentivity to pain with anhidrosis. Chromosomal aberrations involving TrkA are a cause of thyroid papillary carcinoma. |
| 克隆类型： | Mouse Monoclonal Antibody |
| 亚型： | Mouse IgG1 |
| 免疫原： | Purified recombinant extracellular fragment of human TrkA(aa33-423) fused with hIgGFc tag expressed in HEK293 cell line. |
| 适用物种： | H |
| 应用范围： | WB, IF |
| 应用说明： | WB: 1:500-1:2000; IF: 1:200-1:1000; |
| 别名： | High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; p140-TrkA; Trk-A; NTRK1; TRK |
| 形态： | Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存条件： | Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 参考文献： |
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文献和实验和细胞谱系转变，但肿瘤分泌产物的自分泌/旁分泌耐药机制尚不明确。该研究通过蛋白质组学筛查证实，耐药细胞分泌的神经生长因子（NGF）是介导耐药的关键因子，上游SRPK1激酶调控剪接因子SRSF1核积累，促进NGF前体mRNA选择性剪接产生翻译效率更高的proNGF-B亚型，导致NGF蛋白大量产生。分泌的NGF通过受体TrkA激活非经典MEK5-ERK5通路，使肿瘤细胞生存信号从被抑制的经典ERK1/2通路切换至ERK5通路，维持细胞增殖活性。临床研究显示复发肿瘤NGF水平显著高于原发灶，高表达与患者
Intracellular Cytokine Staining Protocol
anti-cytokine antibodies with excess amounts of unlabeled antibody. Alternatively, recombinant cytokines can be used for blocking.eBioscience antibodies are available as Functional Grade (FG) Purified (sterile, endotoxin-tested, no azide), Purified
Fluorochrome Absorption and Emission Spectra
?10-nm bandpass filter will give optimum detection for this fluorochrome (Fig. 1). Comparative staining using a monoclonal antibody (RA3-6B2; anti-B220; Cat. No. 557390/553084**) conjugated
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