CD38 is a 45-kDa single chain type-II transmembrane glycoprotein. It is expressed on thymocytes, activated T and B cells, hematopoietic progenitors and terminally differentiated B cells/plasma cells (at high levels). CD38 antigen is also present on monocytes, dendritic cells, NK cells and some epithelial cells. CD38 is a NAD glycohydrolase and is a regulator of cell activation and proliferation, and also involved in adhesion between human lymphocytes and endothelial cells.
克隆类型:
Mouse Monoclonal Antibody
亚型:
Mouse IgG1
免疫原:
Purified recombinant fragment of human CD38 expressed in E. coli.
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
保存条件:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
参考文献:
Gupta P. et al 2010. Blood. 116(17):3258-67. doi: 10.1182. PMID#20628151. Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias.