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- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
BAY 41-6551 hydrate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1257517-67-1
- 规格：
50 mg/100 mg/500 mg
| 规格： | 50 mg | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥800.0 |
| 规格： | 500 mg | 产品价格： | ￥2000.0 |
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Amikacin hydrate
CAS No. : 1257517-67-1
MCE 国际站：Amikacin hydrate
产品活性：Amikacin hydrate (BAY 41-6551 hydrate) 是一种氨基糖苷类抗生素，也是一种卡那霉素的半合成类似物。Amikacin hydrate 具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。Amikacin hydrate 对大多数革兰氏阴性细菌 (Gram-negative bacteria) (包括庆大霉素和妥布霉素抗性菌株) 非常有效。Amikacin hydrate 还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。
研究领域：Anti-infection
作用靶点：Bacterial | Antibiotic
In Vitro: Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides, Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi).
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50 value of 453 μM.
In Vivo: Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo.
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文献和实验A 28-year-old man was transferred to our hospital and underwent surgery for resection of an aortic graft infected with Klebsiella pneumoniae . Antimicrobial therapy consisted of amikacin, cefazolin, chloramphenicol, sulfamethoxazole
Micellar Electrokinetic Chromatography of Aminoglycosides
The components of the aminoglycosides, e.g., gentamicin, sisomicin, netilmicin, kanamycin, amikacin, and tobramycin, and related impurities of these antibiotics can be separated by means of micellar electrokinetic chromatography (MEKC
Partial proteolysis with Staph. aureus V8 protease
mm (which is the size of the 28-tooth comb wells). Rehydrate the gel pieces in 100 microliters of rehydration/overlay buffer for 1-2 min. Do not over-hydrate. The pieces will become too fragile and will fragment. Place the gel pieces
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