- ￥1600 - 2650
- MultiSciences
- 31.25 pg/mL - 2000 pg/mL
- 杭州
- EK217
- 2026年03月24日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
99
- 供应商：
联科生物
- 检测范围：
31.25 pg/mL - 2000 pg/mL
- 检测方法：
双抗夹心法
- 应用：
ELISA
- 适应物种：
Mouse
- 标记物：
HRP
- 样本：
血清，血浆，细胞培养上清及其他生物学样本
- 规格：
96T/48T
| 规格： | 96T | 产品价格： | ￥2650.0 |
|---|---|---|---|
| 规格： | 48T | 产品价格： | ￥1600.0 |
| 背景介绍 | 白细胞介素17A(IL-17或者IL-17A)，是IL-17家族细胞因子类群中的代表成员。IL-17细胞因子可通过增加组织中趋化因子的产量来有效召集单核细胞和中性粒细胞到炎症部位，从而延缓炎症的发生。IL-17是由辅助型T淋巴细胞产生，可被IL-23诱导。当细胞外的病原体入侵到免疫系统时，作为促炎性细胞因子的IL-17就会发生应答反应，破坏病原体细胞。IL-17可与肿瘤坏死因子和IL-1协调作用，在许多免疫相关疾病，如类风湿性关节炎、哮喘、狼疮、同种异体移植排斥、抗肿瘤免疫力、牛皮癣、多发性硬化症中发挥着重要作用。 |
| 检测原理 | 本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗小鼠IL-17A抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的IL-17A与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IL-17A的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。 |
| 组分 | 包被抗IL-17A单克隆抗体的96孔聚苯乙烯酶标板 小鼠IL-17A冻干标准品 IL-17A检测抗体 标准品稀释液 检测缓冲液(10×) 底物(TMB) 终止液 洗液(20×) 封板膜 |
| 分析类型 | 夹心ELISA |
| 样本类型 | 血清、血浆，细胞培养上清及其他生物学样本 |
| 板式 | 96孔板，可拆 |
| 保存 | 试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。 |
| 运输条件 | 4℃蓝冰运输 |
| 样本体积 | 20 μl |
| 灵敏度 | 0.26 pg/ml |
| 标准曲线范围 | 31.25 - 2000 pg/ml |
| 回收率范围 | 91 %-115 % |
| 平均回收率 | 1.01 |
| 板间变异系数 | 2.8 % - 5.6 % |
| 板内变异系数 | 4.2 % - 8.4 % |
IL17A 分子靶点信息概述
- 分子名：IL17A, interleukin 17A
- 基因家族：Interleukins
- 别名：IL-17A; IL-17
- 曾用名：CTLA8; IL17
- 全称：cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
IL17A 分子靶点综述
IL-17主要由Th17型细胞产生，是目前已发现的30余种白细胞介素中的一员，按序号排在第17位。该家族包括6个成员配体(IL-17A ~ IL-17F)和5个受体(IL-17RA ~ IL-17RD和SEF)。IL-17是一种主要由活化的T细胞产生的致炎细胞因子，可以促进T细胞的激活和刺激上皮细胞、内皮细胞、成纤维细胞产生多种细胞因子，从而导致炎症的产生。
小鼠 Mouse Il17a 分子靶点信息
- 分子名：Il17a, interleukin 17A
- 别称：
- Ctla-8
- Ctla8
- cytotoxic T lymphocyte-associated protein 8
- IL-17A
- Il17
- interleukin 17
- 基因序列：NCBI_Gene: 16171
- 蛋白序列：
- UniprotKB: Q62386
- UniprotKB: Q544E6
小鼠 Mouse Il17a 靶点分子功能（预测）
Enables protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including defense response to other organism; intestinal epithelial structure maintenance; and positive regulation of gene expression. Acts upstream of or within cellular response to interleukin-1; positive regulation of cytokine production involved in inflammatory response; and positive regulation of transcription by RNA polymerase II. Located in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); eye disease (multiple); and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A).
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文献和实验该产品被引用文献
- IF = 17.694 In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitis. Nature Communications (2022)
- IF = 5.858 Madecassic acid alleviates colitis-associated colorectal cancer by blocking the recruitment of myeloid-derived suppressor cells via the inhibition of IL-17 expression in γδT17 cells. BIOCHEMICAL PHARMACOLOGY (2022)
- IF = 4.932 Dihydrosanguinarine based RNA-seq approach couple with network pharmacology attenuates LPS-induced inflammation through TNF/IL-17/PI3K/AKT pathways in mice liver. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
- IF = 4.36 Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. JOURNAL OF ETHNOPHARMACOLOGY (2021)
- IF = 2.942 Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-κB/MAPK pathway. BIOSCIENCE REPORTS (2020)
- IF = 0 Combination of Mesenchymal Stem Cell and Endothelial Progenitor Cell Infusion Accelerates Injured Intestinal Repair by Regulating Gut Microbiota after Hematopoietic Cell Transplantation. Transplantation and Cellular Therapy (2020)
- IF = 4.236 Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway. Frontiers in Microbiology (2020)
- IF = 17.694 Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner. Nature Communications (2022)
- IF = 3.221 miR-485 regulates Th17 generation and pathogenesis in experimental autoimmune encephalomyelitis through targeting STAT3. JOURNAL OF NEUROIMMUNOLOGY (2023)
- IF = 5.34 Proteomics analysis reveals suppression of IL-17 signaling pathways contributed to the therapeutic effects of Jia-Wei Bu-Shen-Yi-Qi formula in a murine asthma model. PHYTOMEDICINE (2021)
- IF = 1.851 Rebamipide ophthalmic solution modulates the ratio of T helper cell 17/regulatory T cells in dry eye disease mice. Molecular Medicine Reports (2019)
- IF = 4.545 1,25(OH)2D3 mitigate cancer-related fatigue in tumor-bearing mice: Integrating network pharmacological analysis. BIOMEDICINE & PHARMACOTHERAPY (2020)
- IF = 3.414 Amelioration of dry eye syndrome in db/db mice with diabetes mellitus by treatment with Tibetan Medicine Formula Jikan Mingmu Drops. JOURNAL OF ETHNOPHARMACOLOGY (2019)
- IF = 4.545 Anti−IL-12/23 p40 antibody attenuates chronic graft-versus-host disease with lupus nephritis via inhibiting Tfh cell in mice. BIOMEDICINE & PHARMACOTHERAPY (2020)
- IF = 3.943 Bacteroides thetaiotaomicron relieves colon inflammation by activating aryl hydrocarbon receptor and modulating CD4+T cell homeostasis. INTERNATIONAL IMMUNOPHARMACOLOGY (2020)
- IF = 3.758 Baicalein Restores the Balance of Th17/Treg Cells via Aryl Hydrocarbon Receptor to Attenuate Colitis. MEDIATORS OF INFLAMMATION (2020)
- IF = 3.831 Berberine Regulates Treg/Th17 Balance to Treat Ulcerative Colitis Through Modulating the Gut Microbiota in the Colon. Frontiers in Pharmacology (2018)
- IF = 2.205 Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways. Bioengineered (2020)
- IF = 5.988 Chang qing formula ameliorates colitis-associated colorectal cancer via suppressing IL-17/NF-κB/STAT3 pathway in mice as revealed by network pharmacology study. Frontiers in Pharmacology (2022)
- IF = 2.557 Disabled-2 overexpression mediates immune suppression in systemic lupus erythematosus by modulating Treg/Th17 cell differentiation. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2022)
- IF = 5.037 Down-regulation of taurine-up-regulated gene 1 attenuates inflammation by sponging miR-9-5p via targeting NF-κB1/p50 in multiple sclerosis. LIFE SCIENCES (2019)
- IF = 2.914 Effects of combined traffic noise on the synaptic ultrastructure and expressions of p-CaMKII and NMDAR1 in the hippocampus of young SD rats. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2019)
- IF = 5.959 Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment. Cell Death & Disease (2019)
- IF = 5.156 High humidity aggravates the severity of arthritis in collagen-induced arthritis mice by upregulating xylitol and L-pyroglutamic acid. ARTHRITIS RESEARCH & THERAPY (2021)
- IF = 4.078 HMGB1-induced ILC2s activate dendritic cells by producing IL-9 in asthmatic mouse model. CELLULAR IMMUNOLOGY (2020)
- IF = 4.183 Human IL-23R Cytokine-Binding Homology Region-Fc Fusion Protein Ameliorates Psoriasis via the Decrease of Systemic Th17 and ILC3 Cell Responses. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
- IF = 7.561 Hyperforin Ameliorates Imiquimod-Induced Psoriasis-Like Murine Skin Inflammation by Modulating IL-17A–Producing γδ T Cells. Frontiers in Immunology (2021)
- IF = 3.777 Hyperoside alleviates postmenopausal osteoporosis via regulating miR-19a-5p/IL-17A axis. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2023)
- IF = 3.32 ILC2 regulates hyperoxia-induced lung injury via an enhanced Th17 cell response in the BPD mouse model. BMC Pulmonary Medicine (2023)
- IF = 1.798 Inhibition of Kruppel-like factor 7 attenuates cell proliferation and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis through NF-κB and MAPK signaling pathway. EXPERIMENTAL ANIMALS (2022)
- IF = 2.273 Inhibition of microRNA-155 attenuates concanavalin-A-induced autoimmune hepatitis by regulating Treg/Th17 cell differentiation. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2018)
- IF = 2.63 Integrated Network Pharmacology and Mice Model to Investigate Qing Zao Fang for Treating Sjögren’s Syndrome. Evidence-based Complementary and Alternative Medicine (2022)
- IF = 1.903 Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication via Inflammation and Fibrosis Inhibition in Mice. CHEMICAL & PHARMACEUTICAL BULLETIN (2023)
- IF = 3.943 LncRNA AK085865 depletion ameliorates asthmatic airway inflammation by modulating macrophage polarization. INTERNATIONAL IMMUNOPHARMACOLOGY (2020)
- IF = 4.258 MAF bZIP Transcription Factor B (MAFB) Protected Against Ovalbumin-Induced Allergic Rhinitis via the Alleviation of Inflammation by Restoring the T Helper (Th) 1/Th2/Th17 Imbalance and Epithelial Barrier Dysfunction. Journal of Asthma and Allergy (2022)
- IF = 2.5 miR-223 improves intestinal inflammation through inhibiting the IL-6/STAT3 signaling pathway in dextran sodium sulfate-induced experimental colitis. Immunity Inflammation and Disease (2020)
- IF = 3.743 Modification effects of SanWei GanJiang Powder on liver and intestinal damage through reversing bile acid homeostasis. BIOMEDICINE & PHARMACOTHERAPY (2019)
- IF = 3.752 Mucosal immunity of mannose-modified chitosan microspheres loaded with the nontyepable Haemophilus influenzae outer membrane protein P6 in BALB/c mice. PLoS One (2022)
- IF = 5.511 NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis. Frontiers in Immunology (2018)
- IF = 5.714 Oral squamous cell carcinoma-derived EVs promote tumor progression by regulating inflammatory cytokines and the IL-17A-induced signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
- IF = 1.798 Oroxylin A inhibited autoimmune hepatitis-induced liver injury and shifted Treg/Th17 balance to Treg differentiation. EXPERIMENTAL ANIMALS (2023)
- IF = 6.388 Potential mechanism of oral baicalin treating psoriasis via suppressing Wnt signaling pathway and inhibiting Th17/IL-17 axis by activating PPARγ. PHYTOTHERAPY RESEARCH (2022)
- IF = 4.174 SMURF1 inhibits the Th17 and Th17.1 polarization and improves the Treg/Th17 imbalance in systemic lupus erythematosus through the ubiquitination of RORγt. MOLECULAR IMMUNOLOGY (2023)
- IF = 4.174 T-cell-specific Sel1L deletion exacerbates EAE by promoting Th1/Th17-cell differentiation. MOLECULAR IMMUNOLOGY (2022)
- IF = 4.813 The effect of inulin-type fructans on the intestinal immune function of antibiotic-treated mice. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2022)
- IF = 2.924 The Effects of Treatment with Icariin on Immune Tolerance in the Recurrent Spontaneous Abortion Mice. Reproductive Sciences (2023)
- IF = 6.458 Therapeutic effects of cationic liposomes on lupus-prone MRL/lpr mice are mediated via inhibition of TLR4-triggered B-cell activation. Nanomedicine-Nanotechnology Biology and Medicine (2021)
- IF = 7.31 TMT-Based Quantitative Proteomic Analysis Reveals Downregulation of ITGAL and Syk by the Effects of Cycloastragenol in OVA-Induced Asthmatic Mice. Oxidative Medicine and Cellular Longevity (2022)
- IF = 4.545 TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model. BIOMEDICINE & PHARMACOTHERAPY (2020)
- IF = 6.388 Transcriptomics reveals apigenin alleviates airway inflammation and epithelial cell apoptosis in allergic asthma via MAPK pathway. PHYTOTHERAPY RESEARCH (2023)
- IF = 3.298 Activation of STAT6 by intranasal allergens correlated with the development of eosinophilic chronic rhinosinusitis in a mouse model:. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2022)
- IF = 3.7 Blocking BAFF Alleviates Hepatic Fibrosis in Schistosoma japonicum-Infected Mice. Pathogens (2023)
- IF = 5.858 MicroRNA let-7g-5p alleviates murine collagen-induced arthritis by inhibiting Th17 cell differentiation. BIOCHEMICAL PHARMACOLOGY (2020)
- IF = 3.124 MicroRNA-143-3p ameliorates collagen-induced arthritis by polarizing naive CD4+T cells into Treg cells. JOURNAL OF CLINICAL LABORATORY ANALYSIS (2023)
- IF = 4.868 MicroRNA-26b-5p alleviates murine collagen-induced arthritis by modulating Th17 cell plasticity. CELLULAR IMMUNOLOGY (2021)
- IF = 3.889 Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation. PHARMACEUTICAL BIOLOGY (2023)
- IF = 2.73 Triptolide inhibits Th17 differentiation via controlling PKM2-mediated glycolysis in rheumatoid arthritis. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2022)
- IF = 0.533 Effect of prednisone on IL-17 secretion in maternal-fetal immune rejection cell model, and on IL-23/IL-17 inflammation axis. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH (2021)
- IF = 6.575 Huangshan Floral Mushroom Polysaccharide Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulating Th17/treg Balance in a Gut Microbiota-Dependent Manner. MOLECULAR NUTRITION & FOOD RESEARCH (2022)
- IF = 4.451 Immunomodulatory activity of purified polysaccharides from Rubus chingii Hu fruits in lymphocytes and its molecular mechanisms. Journal of Functional Foods (2021)
- IF = 5.811 Isovitexin Inhibits Ginkgolic Acids-Induced Inflammation Through Downregulating SHP2 Activation. Frontiers in Pharmacology (2021)
- IF = 5.811 Modified Gegen Qinlian Decoction Regulates Treg/Th17 Balance to Ameliorate DSS-Induced Acute Experimental Colitis in Mice by Altering the Gut Microbiota. Frontiers in Pharmacology (2021)
相关实验
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 小鼠白介素-17A (IL-17A)ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗小鼠 IL-17A 单抗包被于酶标板上，标准品和样品中的 IL-17A与单抗结合，加入生物
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人白细胞介素-17A（IL-17A）酶联免疫分析（ELISA）
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Mouse IL-17A ELISA Kit（小鼠白介素17A ELISA试剂盒）
￥1600 - 2650
