- ￥2260
- LSM Bio
- 进口
- PAab09938
- 2025年07月14日
- ELISA, IHC, WB,IF
- E. coli - derived recombinant protein
- Human, Mouse, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
caspase 3, apoptosis-related cysteine peptidase
- 亚型：
IgG1
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
monoclonal
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse, Rat
- 保质期：
6个月
- 抗原来源：
Mouse
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, IHC, WB,IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
caspase 3, apoptosis-related cysteine peptidase
- 抗体英文名：
CASP3 antibody
- 抗体名：
CASP3 antibody
- 规格：
100μl
CASP3 antibody
Product Name CASP3 antibody
Catalog No PAab09938
Packing 100ul
Form liquid
Alternative Name Apopain, CASP 3, CASP3, Caspase 3, Caspase 3/p17, Caspase3, CPP 32, CPP32, CPP32B, Cysteine protease CPP32, Protein Yama, SCA 1, SREBP cleavage activity 1
Purification protein A+G purified
Purity 95% as determined by SDS-PAGE
Host Mouse
Isotype IgG1
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase(PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
Immunogen caspase 3, apoptosis-related cysteine peptidase
Specificity Human, Mouse, Rat
Tested Application ELISA, IHC, WB,IF
Recommended dilution WB: 1:500-1:2000; IHC: 1:50-1:300; IF: 1:50-1:200
IHC use Immunohistochemistry of paraffin-embedded human breast cancer using PAab09938(CASP3 antibody) at dilution of 1:200
WB use
Untreated and Staurosporine treated Jurkat cells were subjected to SDS PAGE followed by western blot with PAab09938 (CASP3 antibody) at dilution of 1:3000
Protein Information
Gene ID 836
Uniprot ID P42574
Calculated MW 32-35 kDa, 19 kDa, 17 kDa
Research Area Cancer, Metabolism, Neuroscience
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文献和实验日本理化研究所研究人员日前宣布，他们发现了与川崎病发病有关的基因，这一基因只要出现微小差异，川崎病的发病风险就会大幅提高。 理化研究所基因组医学研究中心发布公报说，该中心研究人员此前依靠全基因组扫描，发现有10个基因组区域与川崎病相关。在这次研究中，他们重点调查了其中的4号染色体上的区域，发现基因CASP3的一处单核苷酸多态性与川崎病的发病相关。他们分析了约900名川崎病患者和约1400名正常人的CASP3基因后发现，如果存在这处单核苷酸多态性，川崎病的发病风险就会提高至1.4倍。 单核
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
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