- ￥2260
- LSM Bio
- 进口
- PAab09837
- 2025年07月17日
- ELISA, WB, IHC
- E. coli - derived recombinant protein
- Human, Mouse, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
toll-like receptor 4
- 亚型：
IgG2b
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
monoclonal
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse, Rat
- 保质期：
6个月
- 抗原来源：
Mouse
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, WB, IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
toll-like receptor 4
- 抗体英文名：
TLR4 antibody
- 抗体名：
TLR4 antibody
- 规格：
100μl
TLR4 antibody
Product Name TLR4 antibody
Catalog No PAab09837
Packing 100ul
Form liquid
Alternative Name ARMD10, CD284, hToll, TLR4, TOLL, toll like receptor 4
Purification Protein A+G purification
Purity 95% as determined by SDS-PAGE
Host Mouse
Isotype IgG2b
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
TLR4, also named as CD284, belongs to the Toll-like receptor family. TLR4 cooperates with LY96 and CD14 to mediates the innate immune response to bacterial lipopolysaccharide (LPS). TLR4 acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
Immunogen toll-like receptor 4
Specificity Human, Mouse, Rat
Tested Application ELISA, WB, IHC
Recommended dilution WB: 1:1000-1:8000; IHC: 1:50-1:500
IHC use Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using PAab09837( TLR4 Antibody) at dilution of 1:200
WB use
RAW 264.7 cells were subjected to SDS PAGE followed by western blot with PAab09837( TLR4 Antibody) at dilution of 1:4000
Protein Information
Gene ID 7099
Uniprot ID O00206
Calculated MW 35 kDa
Research Area Neuroscience, Immunology, Signal Transduction, Developmental biology
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文献和实验因为journal club要讲文章 顺便儿拿来和大家讨论下 Hmgb1调节TLR4介导的angiogenesis 最近才开始关注这个蛋白。这篇文章已经在线发表在atvb上，由中山医眼科中心完成的工作。 Hmgb1不仅可以作为一种nuclear factor, 而且还可以作为cytokine来介导感染引起的炎症，免疫损伤。Hmgb1已经在sepsis, arthritis, 肿瘤和其他多种疾病中明确了其作用。Hmgb1可以结合tlr2/4，并且通过MyD88依赖性信号通路促进
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
人 Toll 样受体 4(TLR4) 酶联免疫分析 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，细胞上清及相关液体样本中 Toll 样受体4(TLR4) 的含量。 实验原理： 本试剂盒应用双抗体夹心法测定标本中 人 Toll 样受体4(TLR4) 水平。用纯化的人 Toll 样受体4(TLR4) 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 Toll 样受体4(TLR4
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