- ￥2250
- LSM Bio
- 进口
- PAab10112
- 2025年07月05日
- ELISA, IHC, WB, IF
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
cadherin 1, type 1, E-cadherin (epithelial)
- 亚型：
IgG2b
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
monoclonal
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Mouse
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, IHC, WB, IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
cadherin 1, type 1, E-cadherin (epithelial)
- 抗体英文名：
E-cadherin antibody
- 抗体名：
E-cadherin antibody
- 规格：
100μl
E-cadherin antibody
Product Name E-cadherin antibody
Catalog No PAab10112
Packing 100ul
Form liquid
Alternative Name Arc 1, Cadherin 1, CD324, CDH1, CDHE, E cadherin, ECAD, E-cadherin, LCAM, UVO, Uvomorulin
Purification protein A+G purified
Purity 95% as determined by SDS-PAGE
Host Mouse
Isotype IgG2b
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Immunogen cadherin 1, type 1, E-cadherin (epithelial)
Specificity Human
Tested Application ELISA, IHC, WB, IF
Recommended dilution WB: 1:1000-1:5000; IHC: 1:500-1:2000; IF: 1:50-1:500
IHC use Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using PAab10112( E-cadherin Antibody) at dilution of 1:1000
WB use
A431 cells were subjected to SDS PAGE followed by western blot with PAab10112(E-cadherin antibody) at dilution of 1:3000
Protein Information
Gene ID 999
Uniprot ID P12830
Calculated MW 130 kDa
Research Area Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Stem Cells
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文献和实验Tracking the Transport of E-Cadherin to and From the Plasma Membrane
, it is also a key occurrence in many diseases, including cancers of epithelial origin E-cadherin is a central component of adherens junctions (AJs), which act as structural and signaling hubs in epithelial cells that oppose EMT. The loss of E-cadherin
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
with purified proteins. The methods described here overcome these problems. Using a mammalian expression system, a chimeric protein comprising the extracellular domain of E-cadherin fused at its C-terminus to the Fc domain of human IgG1 (E-cadherin∶Fc
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