- ￥2062.50
- LSM Bio
- CHINA
- PAab10079
- 2025年07月17日
- ELISA, IHC
- Rabbit
- Human
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- 详细信息
- 技术资料
- 免疫原：
platelet-derived growth factor receptor, beta polypeptide
- 亚型：
IgG
- 形态：
liquid
- 克隆性：
单克隆
- 适应物种：
Human
- 保质期：
12 month
- 库存：
50
- 供应商：
LSM bio
- 宿主：
Rabbit
- 应用范围：
ELISA, IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 抗体英文名：
PDGFRB antibody
- 抗体名：
PDGFRB antibody
- 规格：
100ul
PDGFRB antibody
Product Name PDGFRB antibody
Catalog No PAab10079
Packing 100ul
Form liquid
Alternative Name PDGFR, PDGFR1
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes(mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands-homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD-leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
Immunogen platelet-derived growth factor receptor, beta polypeptide
Specificity Human
Tested Application ELISA, IHC
Recommended dilution IHC: 1:20-1:200
IHC use Immunohistochemistry of paraffin-embedded human kidney tissue slide using PAab10079(PDGFRB Antibody) at dilution of 1:200
WB use
Protein Information
Gene ID 5159
Uniprot ID P09619
Calculated MW
Research Area Signal Transduction, Metabolism, Cancer, Immunology, Developmental biology
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