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- 详细信息
- 文献和实验
- 技术资料
- 库存：
99
- 供应商：
联科生物
- 检测范围：
0.78 pg/mL - 50 pg/mL
- 检测方法：
双抗夹心法
- 应用：
ELISA
- 适应物种：
Human
- 标记物：
HRP
- 样本：
血清，血浆，细胞培养上清及其他生物学样本
- 规格：
96T/48T
| 规格： | 96T | 产品价格： | ￥3400.0 |
|---|---|---|---|
| 规格： | 48T | 产品价格： | ￥2000.0 |
| 背景介绍 | 白细胞介素17A(IL-17或者IL-17A)，是IL-17家族细胞因子类群中的代表成员，由辅助型T淋巴细胞产生，可被IL-23诱导。IL-17细胞因子可通过增加组织中趋化因子的产量来有效招募单核细胞和中性粒细胞到炎症部位，从而延缓炎症的发生。当细胞外的病原体入侵到免疫系统时，作为促炎性细胞因子的IL-17就会发生应答反应，破坏病原体细胞。IL-17可与肿瘤坏死因子和IL-1发挥协同作用。IL-17家族与许多免疫/自身免疫相关疾病有关，如类风湿性关节炎、哮喘、狼疮、同种异体移植排斥、抗肿瘤免疫力、牛皮癣、多发性硬化症。 |
| 检测原理 | 本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人IL-17A抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的IL-17A与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IL-17A的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。 |
| 组分 | 包被抗IL-17A单克隆抗体的96孔聚苯乙烯酶标板 人IL-17A冻干标准品 IL-17A检测抗体 标准品稀释液 辣根过氧化物酶标记的链霉亲和素 信号增强剂浓缩液 信号增强剂稀释液 检测缓冲液(10×) 底物(TMB) 终止液 洗液(20×) |
| 分析类型 | 夹心ELISA |
| 样本类型 | 血清、血浆，细胞培养上清及其他生物学样本 |
| 板式 | 96孔板，可拆 |
| 保存 | 试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。 |
| 运输条件 | 4℃蓝冰运输 |
| 样本体积 | 血清血浆：20 μl 细胞培养上清：100μl |
| 灵敏度 | 0.20 pg/ml |
| 标准曲线范围 | 0.78 - 50 pg/ml |
| 回收率范围 | 80%-95% |
| 平均回收率 | 0.86 |
| 板间变异系数 | 5.9 % - 9.0% |
| 板内变异系数 | 4.3 % - 4.6 % |
IL17A 分子靶点信息概述
- 分子名：IL17A, interleukin 17A
- 基因家族：Interleukins
- 别名：IL-17A; IL-17
- 曾用名：CTLA8; IL17
- 全称：cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
IL17A 分子靶点综述
IL-17主要由Th17型细胞产生，是目前已发现的30余种白细胞介素中的一员，按序号排在第17位。该家族包括6个成员配体(IL-17A ~ IL-17F)和5个受体(IL-17RA ~ IL-17RD和SEF)。IL-17是一种主要由活化的T细胞产生的致炎细胞因子，可以促进T细胞的激活和刺激上皮细胞、内皮细胞、成纤维细胞产生多种细胞因子，从而导致炎症的产生。
人 Human IL17A 分子靶点信息
- 分子名：IL17A, interleukin 17A
- 别称：
- CTLA-8
- CTLA8
- cytotoxic T-lymphocyte-associated antigen 8
- cytotoxic T-lymphocyte-associated protein 8
- cytotoxic T-lymphocyte-associated serine esterase 8
- IL-17
- IL-17A
- IL17
- ILA17
- interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
- interleukin-17
- interleukin-17A
- 基因序列：NCBI_Gene: 3605
- 蛋白序列：UniProtKB: Q16552
人 Human IL17A靶点分子功能（预测）
Predicted to enable cytokine activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of osteoclast differentiation. Acts upstream of or within positive regulation of cytokine production and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular region. Implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Biomarker of several diseases, including acne; autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and rhinitis (multiple).
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- IF = 17.521 Tonsillar Microbiome-Derived Lantibiotics Induce Structural Changes of IL-6 and IL-21 Receptors and Modulate Host Immunity. Advanced Science (2022)
- IF = 8.786 A metagenome-wide association study of the gut microbiota in recurrent aphthous ulcer and regulation by thalidomide.. Frontiers in Immunology (2022)
- IF = 8.74 The STING antagonist H-151 ameliorates psoriasis via suppression of STING/NF-κB-mediated inflammation. BRITISH JOURNAL OF PHARMACOLOGY (2021)
- IF = 7.658 RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer. PHARMACOLOGICAL RESEARCH (2021)
- IF = 7.561 Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples.. Frontiers in Immunology (2021)
- IF = 6.53 Glycolysis aggravates methotrexate toxicity by fueling RFC1-controlled intestinal absorption in rheumatic rats. BIOMEDICINE & PHARMACOTHERAPY (2022)
- IF = 5.988 Metabolomics Profiles Associated with the Treatment of Zuojin Pill on Patients with Chronic Nonatrophic Gastritis. Frontiers in Pharmacology (2022)
- IF = 5.211 Involvement of impaired CD8+ mucosal-associated invariant T cells and myeloid-derived suppressor cells in polycystic ovary syndrome. Reproductive Biology and Endocrinology (2021)
- IF = 5.195 Modified Gegen Qinlian decoction ameliorated ulcerative colitis by attenuating inflammation and oxidative stress and enhancing intestinal barrier function in vivo and in vitro. JOURNAL OF ETHNOPHARMACOLOGY (2023)
- IF = 5.085 Increased AHR Transcripts Correlate With Pro-inflammatory T-Helper Lymphocytes Polarization in Both Metabolically Healthy Obesity and Type 2 Diabetic Patients. Frontiers in Immunology (2020)
- IF = 4.932 Berberine inhibits dendritic cells differentiation in DSS-induced colitis by promoting Bacteroides fragilis. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
- IF = 4.868 MicroRNA-26b-5p alleviates murine collagen-induced arthritis by modulating Th17 cell plasticity. CELLULAR IMMUNOLOGY (2021)
- IF = 4.631 Fibrinogen-Like Protein 1 as a Novel Biomarker of Psoriasis Severity. Journal of Inflammation Research (2022)
- IF = 4.407 Interleukin-35 inhibits angiogenesis through T helper17/ Interleukin-17 related signaling pathways in IL-1β-stimulated SW1353 cells. MOLECULAR IMMUNOLOGY (2022)
- IF = 4.207 Participation of Increased Circulating MAIT Cells in Lung Cancer: a Pilot Study. Journal of Cancer (2022)
- IF = 3.777 Hyperoside alleviates postmenopausal osteoporosis via regulating miR-19a-5p/IL-17A axis. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2023)
- IF = 3.687 Changes of Th17/Tc17 and Th17/Treg cells in endometrial carcinoma. GYNECOLOGIC ONCOLOGY (2014)
- IF = 3.65 Imbalance of Th17, Treg, and helper innate lymphoid cell in the peripheral blood of patients with rheumatoid arthritis. CLINICAL RHEUMATOLOGY (2022)
- IF = 3.633 Vitamin D deficiency is associated with thyroid autoimmunity: results from an epidemiological survey in Tianjin, China. ENDOCRINE (2021)
- IF = 3.534 Elevated Peripheral Frequencies of Th22 Cells: A Novel Potent Participant in Obesity and Type 2 Diabetes. PLoS One (2014)
- IF = 3.361 Interleukin-25 is upregulated in patients with systemic lupus erythematosus and ameliorates murine lupus by inhibiting inflammatory cytokine production. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
- IF = 3.208 Total extract of Xin Jia Xuan Bai Cheng Qi decoction inhibits pulmonary fibrosis via the TGF-β/Smad signaling pathways in vivo and in vitro. Drug Design Development and Therapy (2019)
- IF = 3.124 MicroRNA-143-3p ameliorates collagen-induced arthritis by polarizing naive CD4+T cells into Treg cells. JOURNAL OF CLINICAL LABORATORY ANALYSIS (2023)
- IF = 3.061 Targeting the class IA PI3K isoforms p110α/δ attenuates heart allograft rejection in mice by suppressing the CD4+ T lymphocyte response. American Journal of Translational Research (2018)
- IF = 3.028 Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses. Drug Design Development and Therapy (2015)
- IF = 2.747 Immunomodulatory effects of platelets on the severity of hand, foot, and mouth disease infected with enterovirus 71. PEDIATRIC RESEARCH (2020)
- IF = 2.73 Triptolide inhibits Th17 differentiation via controlling PKM2-mediated glycolysis in rheumatoid arthritis. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2022)
- IF = 2.664 Basal level of Th17 immune response is not enhanced in aplastic amemia. CYTOKINE (2015)
- IF = 2.589 CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study. Reproductive Biology and Endocrinology (2019)
- IF = 2.535 Distribution of Th17 cells and Foxp3-expressing T cells in tumor-infiltrating lymphocytes in patients with uterine cervical cancer. CLINICA CHIMICA ACTA (2012)
- IF = 2.066 Involvement of interleukin-21 in the pathophysiology of aplastic anemia. EUROPEAN JOURNAL OF HAEMATOLOGY (2015)
- IF = 1.848 Colorectal Cancer Progression Is Associated with Accumulation of Th17 Lymphocytes in Tumor Tissues and Increased Serum Levels of Interleukin-6. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2014)
- IF = 1.513 Low Ratio of Treg to Th17 Cells After 36 Weeks of Telbivudine Therapy Predict HBeAg Seroconversion. VIRAL IMMUNOLOGY (2016)
- IF = 0.719 Differentiation of T-helper cells in distinct phases of atopic dermatitis involves Th1/Th2 and Th17/Treg:. European Journal of Inflammation (2017)
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- IF = 0 Vitamin D Deficiency Contributes to the Reduction and Impaired Function of Naïve Regulatory T Cell in Chronic Heart Failure. Journal of Immunology Research (2015)
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人白细胞介素-17A（IL-17A）酶联免疫分析（ELISA）
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