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- 人/动物/植物
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
97
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
human CD19-FITC
- 抗体名：
FITC标记小鼠抗人CD19单克隆抗体
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
25T/100T
| 规格： | 25T | 产品价格： | ¥528.0 |
|---|---|---|---|
| 规格： | 100T | 产品价格： | ¥1200.0 |
英文名称 : human CD19-FITC
中文名称 : FITC标记小鼠抗人CD19单克隆抗体
别 名 : Antibody deficiency due to defect in CD19, included; AW495831; B lymphocyte antigen CD19; B lymphocyte surface antigen B4; B4; CD 19; CD19 antigen; CD19 molecule; Cd19 protein; Differentiation Antigen CD19; Leu 12; Leu12; Lymphocyte Surface Antigen; MGC109570; MGC12802; T-cell surface antigen Leu-12; CD19_HUMAN.
研究领域 : 细胞生物 免疫学 干细胞 细胞表面分子 淋巴细胞 b-淋巴细胞
抗体来源 : Mouse
克隆类型 : Monoclonal
克 隆 号 : HI19a
交叉反应 : Human,
产品应用 : Flow-Cyt=20ul/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 59kDa
细胞定位 : 细胞膜
性 状 : Liquid
亚 型 : IgG
纯化方法 : affinity purified by Protein G
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : CD19 is a transmembrane glycoprotein that is delectively expressed on the cell surface of B-lymphocytes,where it activates intracellular signaling cascades involving both Ras and phosphatidylinositol 3-kinase pathways.Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Function:
Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Subunit:
Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Post-translational modifications:
Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.
DISEASE:
Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
SWISS:
P25918
Gene ID:
930
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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