- ¥1580 - 2480
- gelatins
- jlcR8541
- 国内
- 2025年07月11日
- WB,ELISA等
- 人/动物/植物
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
175
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
CLEC 4E
- 抗体名：
C型凝集素4家族E抗体
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
100ul/200ul
| 规格： | 100ul | 产品价格： | ¥1580.0 |
|---|---|---|---|
| 规格： | 200ul | 产品价格： | ¥2480.0 |
英文名称 : CLEC 4E
中文名称 : C型凝集素4家族E抗体
别 名 : C type lectin domain family 4 member E; C type lectin superfamily member 9; C-type (calcium dependent carbohydrate recognition domain) lectin superfamily member 9; C-type lectin domain family 4 member E; C-type lectin superfamily member 9; CLC4E_HUMAN; CLEC 4E; CLEC4E Clec4e; CLECSF9; Macrophage inducible C type lectin; Macrophage-inducible C-type lectin; MINCLE.
研究领域 : 细胞生物 信号转导 细胞凋亡
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Cow, Horse,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=5μg/Test IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 25kDa
细胞定位 : 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human CLECSF9:51-150/219 <Extracellular>
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
Function:
C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
Subunit:
Monomer. Homodimer.
Subcellular Location:
Membrane.
Similarity:
Contains 1 C-type lectin domain.
SWISS:
Q9ULY5
Gene ID:
26253
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验杀伤细胞凝集素样受体（ KLR ） 属C型凝集素家族成员，为Ⅱ型膜蛋白，由CD94和C型凝集素家族不同成员组成。CD94／NKG2A和CD94／NKG2B，由CD94和NKG2A或NKG2B以二硫键连接，两条肽链的膜外区各有一个C型凝集素样(C-lectin)结构域。其中NKG2A和NKG2B分子胞质区有2个ITIM；CD94无此结构，但起着分子伴侣的作用，对CD94／NKG2A的表达及功能行使是不可少的。 CD94／NKG
WSXWS基序。 3．细胞因子受体结构域 由100个左右氨基酸残基组成，常与Fn3结构域相连，其6―折叠同Fn3和IgSFC2结构域的折叠相似。 4．整合素(integrin)家族 成员是由αβ两条链组成的异源二聚体，某些。链中有一个插入序列，或称I结构域。 5．C型凝集素结构域 常以二聚体形式(如CD69、CD72、CD94／NKG2、CDl61)或三聚体形式(CD23)存在；在选择素分子中，C型凝集素结构域与EGF和CCP
的PECAM-1、NCAM-1和NCAM-L1等分子。 选择素(selectin)最初称为凝集素细胞黏附分子(1ectincelladhesionmolecule，LEC-CAM)，为I型膜分子，胞膜外区均由3种结构域构成：①氨基端约120个氨基酸残基为钙离子依赖的C型外源凝集素样结构域，是选择素分子与配体的结合部位；②表皮生长因子样结构域(EGF-likedomain)，约含35个氨基酸残基，此结构域对维持选择素分子的构象是必需的；③近膜部分是数个约60个氨基酸残基构成的CCP结构域，其作用
