细胞松弛素 D

Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem

General description

A cell-permeable fungal toxin that is approximately 10 times more potent than cytochalasin B in inhibiting actin filament function. Does not inhibit monosaccharide transport across cell membranes. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments at 10 µM. Inactivates low conductance K⁺ channels. Also modulates CD4 cross-linking in T lymphocytes and increases intracellular Ca²⁺ levels. Cytochalasin D also exhibits antibiotic and anti-tumor activity.

Cell-permeable fungal toxin. About 10-fold more potent than cytochalasin B in inhibiting actin filament function. Does not inhibit monosaccharide transport across cell membranes. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inactivates low conductance K⁺ channels. Also modulates CD4 cross-linking in T lymphocytes and increases intracellular Ca²⁺ levels. Exhibits antitumor activity. Also available as a 10 mM solution in DMSO (Cat. No. 504776).

Biochem/physiol Actions

Primary Target
Actin filament function

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