Abemaciclib metabolite M2,1231

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Abemaciclib metabolite M2

CAS No. : 1231930-57-6

MCE 国际站：Abemaciclib metabolite M2

产品活性：Abemaciclib metabolite M2 (LSN2839567) 是 Abemaciclib 的代谢物，为有效的 CDK4 和 CDK6 抑制剂，IC₅₀ 值分别为 1.2 nM 和 1.3 nM。具有抗肿瘤活性。

研究领域：Cell Cycle/DNA Damage  |  Metabolic Enzyme/Protease

作用靶点：CDK  |  Drug Metabolite

In Vivo: Abemaciclib metabolite M2 (LSN2839567) is bound to plasma proteins in rat, dog and human (83-92%), lower than Abemaciclib (95-99%).
?Abemaciclib metabolite M2 is the most prominent (active and major) plasma metabolites in human.

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