Glycycoumarin甘草香豆素,94805-82-0

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Glycycoumarin

CAS No. : 94805-82-0

MCE 国际站：Glycycoumarin

产品活性：Glycycoumarin 是一种有效的抗痉挛剂。Glycycoumarin 是甘草的主要生物活性香豆素，具有抗痉挛活性。Glycycoumarin 还具有保肝作用。Glycycoumarin 可用于腹痛和肝脏疾病的研究。

研究领域：NF-κB  |  PI3K/Akt/mTOR  |  Epigenetics

作用靶点：Keap1-Nrf2  |  AMPK

In Vitro: Glycycoumarin, (25 μM; 24 h) combining with ABT-737 (12.5 μM) synergistically, induces cell death in multiple types of liver cancer cell HepG2.
Glycycoumarin is highly effective against alcoholic liver disease, nonalcoholic fatty liver disease, acetaminophen-induced hepatotoxicity, and liver cancer through mechanisms involved in activation of Nrf2 antioxidant system, stimulation of AMPK-mediated energy homeostasis, induction of autophagy degradation process, and inhibiting oncogenic kinase T-lymphokine-activated killer cell-originated protein kinase activity.

In Vivo: Glycycoumarin (30 μM-0.3 nM; 5 min) has an inhibitory effect on smooth muscle contraction induced by various types of stimulants through the inhibition of PDEs, especially isozyme 3, followed by the accumulation of intracellular cAMP.Glycycoumarin (10 mg/kg; i.p.; once daily for 4 d) enhances tumor growth inhibition in HepG2 xenograft model in mice and shows synergistical effect with ABT-737 (HY-50907).

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  NF-κB Signaling Compound Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Lipid Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Medicine Food Homology Compound Library  |  Phenols Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Transcription Factor-Targeted Library  |  Lipid Metabolism Compound Library   |  Glucose Metabolism Compound Library  |  Food-Sourced Compound Library   |  Anti-Cancer Natural Product Library  |  Anti-inflammatory Traditional Chinese Medicine Active Compound Library  |  Plant-Sourced Natural Product Library  |  Human Metabolite Library  |  Pain-Related Compound Library  |  Doxorubicin hydrochloride  |  Dorsomorphin  |  ML385  |  Metformin  |  AICAR  |  Resveratrol  |  Curcumin  |  4-Octyl itaconate  |  Sulforaphane  |  TBHQ  |  Luteolin  |  Dimethyl fumarate  |  A-769662  |  Bardoxolone methyl  |  Omaveloxolone  |  KI696  |  MK8722  |  Bempedoic acid  |  Brusatol  |  GSK-690693  |  Ezetimibe  |  Oltipraz  |  BAY-3827  |  Carnosol  |  Hinokitiol  |  Aldometanib

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds