Agnuside穗花牡荆苷,11027-63-7

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Agnuside

CAS No. : 11027-63-7

MCE 国际站：Agnuside

产品活性：Agnuside 能够用于哮喘，炎症，血管生成疾病的研究。Agnuside是一种口服有效的可以从黄荆中提取的化合物。

研究领域：Immunology/Inflammation  |  Apoptosis  |  Metabolic Enzyme/Protease

作用靶点：NO Synthase  |  COX  |  Caspase  |  HIF/HIF Prolyl-Hydroxylase  |  ASCT

In Vitro: Agnuside (100 μM, 12-20 h) decreases the expression of iNOS, COX-2 and IL-8 proteins, and has anti-inflammatory effect in RAW264.7 and HT-29 cells stimulated by LPS (1 μg/mL/100 ng/mL) .
Agnuside (0.1-2500 ng/mL, 20-96 h) promotes angiogenesis in HUVEC by promoting cell proliferation (EC₅₀= 1.376 µg/mL) in a time- and dose-dependent manner.
Agnuside (3 μM, 4 h) significantly reduces the levels of caspase-1, ASC, NLRP3, HIF-1α, IL-1β and IL-18 to inhibit inflammation in LPS (10 μg/ml) -stimulated fibroblast-like synoviocytes (FLSs).

In Vivo: Agnuside (6.25 mg/kg; Oral administration; Single dose) reduces the levels of allergic inflammatory mediators in a dose-dependent manner and can inhibit allergic inflammation in Balb/C mice.Agnuside (6.25 mg/kg; Oral administration; Single dose) can inhibit autophagy in allergic asthma in Balb/C mice .Agnuside (6.25 mg/kg; Oral administration; single dose) can reduce synovitis and fibrosis in knee osteoarthritis (KOA) in MIA-induced KOA mice.

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