Nimbolide印苦楝内酯,25990-37-8

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Nimbolide

CAS No. : 25990-37-8

MCE 国际站：Nimbolide

产品活性：Nimbolide 是可以从印楝 (Azadirachta indica) 中分离得到的一种三萜化合物，具有抗癌和抗增殖活性。Nimbolide 通过抑制 NF-κB 和 CDK4/CDK6 激酶，诱导肿瘤细胞凋亡。Nimbolide 抑制 Wnt、PI3K-Akt、MAPK 和 JAK-STAT 信号通路。

研究领域：NF-κB  |  Cell Cycle/DNA Damage  |  Apoptosis

作用靶点：NF-κB  |  CDK  |  Apoptosis

In Vitro: Nimbolide (2 μM, 1-2 h) blocks growth factor-induced phosphorylation of Akt, ERK1/2, and STAT3 in U87EGFRvIII cells.
Nimbolide (2-6 μM, 24 h) inhibits the IGF-I-mediated breast cancer cell proliferation in MCF-7/MDA-MB-231 cells.
Nimbolide (2-6 μM, 24 h) inhibits proliferation and causes G0/G1-phase arrest through repression of cyclins (A1/B/C/D1/E1) in MCF-7/MDA-MB-231 cells.
Nimbolide (0-6 μM, 30 min) increases the expression of DUSP4, increases E-cadherin, Snail and MMP-3 expression.
Nimbolide (0-6 μM, 12 h) suppresses invasion and migration of NSCLC cells.
Nimbolide (0-10 μM, 12 h) inhibits proliferation and induces apoptosis in colorectal cancer cells.
Nimbolide (10 μM, 0-12 h) inhibits NF-κB activation in HCT-116/HT-29/Caco-2 cells by a time-dependent manner.

In Vivo: Nimbolide (10 mg/kg, i.v., daily, 7 days) inhibits glioblastoma multiforme tumor growth in U87EGFRvⅢ xenografted mouse model.
Nimbolide (5 mg/kg, 20 mg/kg; i.p.; daily, 10 days), inhibits tumor growth in HCT-116-derived xenograft mouse, reduces the expression of proteins involved in invasion, metastasis, and angiogenesis (MMP-9, CXCR4, ICAM-1, and VEGF).

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