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OAC2
CAS No. : 6019-39-2
MCE 国际站：OAC2
产品活性：OAC2是Oct4激活化合物，其通过Oct4基因启动子激活表达。
研究领域：Stem Cell/Wnt
作用靶点：Oct3/4
In Vitro: Octamer-binding transcription factor 4 (Oct4) is a master regulator of the induction and maintenance of cellular pluripotency, and has crucial roles in early stages of differentiation. It is the only factor that cannot be substituted by other members of the same protein family to induce pluripotency. Oct4 has been shown to be an essential regulator of embryonic stem cell (ESC) pluripotency and key to the reprogramming process. OAC2 is a structural analog of OAC1. OAC2 activates both Oct4 and Nanog reporters to a similar extent as OAC1. OAC1 and its two structural analogs OAC2 and OAC3 enhances reprogramming efficiency fourfold, up to as high as 2.75%, and accelerates the appearance of iPSC colonies 3 to 4 d when used in combination with the four reprogramming factors, Oct4, Sox2, Klf4, and c-Myc.
相关产品：Bioactive Compound Library Plus | Stem Cell Signaling Compound Library | Anti-Aging Compound Library | Transcription Factor-Targeted Library | Targeted Diversity Library | OAC1 | O4I2 | O4I1 | Oct3/4-inducer-1 | Oct4 inducer-1 | Trimebutine maleate | Oct4 inducer-2
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