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| 规格： | 1 mg | 产品价格： | ￥510.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1275.0 |
| 规格： | 10 mg | 产品价格： | ￥2000.0 |
| 规格： | 25 mg | 产品价格： | ￥3825.0 |
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M435-1279
CAS No. : 1359431-16-5
MCE 国际站：M435-1279
产品活性：M435-1279 是 UBE2T 抑制剂。M435-1279 通过阻断 UBE2T 介导的 RACK1 降解来抑制 Wnt/β-catenin 信号通路的过度激活。
研究领域：Metabolic Enzyme/Protease
作用靶点：E1/E2/E3 Enzyme
In Vitro: M435-1279 (0, 2, 4, 8, 16, 31 μM; 48?h) significantly inhibits the growth of HGC27, AGS, and MKN45 cells[1].
?M435-1279 (0, 4, 8, 12, 16, 20 μM) inhibits the cell viability with IC50s of 16.8, 11.88, 6.93, 7.76 μM of GES-1, HGC27, MKN45, AGS cells, respectively[1].
?M435-1279 (31?nM to 500?μM) binds to UBE2T with a KD value of 50.5?μM[1].
?M435-1279 (11.88?μM; 48?h) inhibits the ubiquitination of RACK1 and the hyperactivation of the Wnt/β-catenin pathway[1].
In Vivo: M435-1279 (5?mg/kg/day; intratumor injection for 18 days) slows the tumor growth[1].
?M435-1279 induces higher RACK1 proteins expression, and lower Ki-67 and β-catenin proteins expression in intratumor tumors[1].
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文献和实验A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H. Advances in the development of biomarkers for epilepsy. Lancet Neurol. 2016 Jul;15(8):843-856. doi: 10.1016/S1474-4422(16)00112-5. PMID: 27302363.
., Jarvis, R., Pallotta, V., Byrom, M., and Ford, L. (2002) RNA interference in mammalian cell culture: design, execution, and analysis of the siRNA effect. Ambion TechNotes 9(1): 3-5. 4. Sui, G., Soohoo, C., Affar, E.B., Gay, F., Shi, Y., Forrester, W.C
Single tube confirmation PCR protocol
concentration of ~10 µM). We use 5 µl of each primer in 50 µl PCR reactions (~ 1 µM final primer concentration). - Label 20 thin-wall PCR tubes (5 for each isolate) and add the following primer pairs: A-B, A-kanB, C-D, kanC-D, and A-D. Tubes 1-5
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