JNJ-37822681,2108806-02-4

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JNJ-37822681 dihydrochloride

CAS No. : 2108806-02-4

MCE 国际站：JNJ-37822681 dihydrochloride

产品活性：JNJ-37822681 dihydrochloride 是一种高效、特异性、有中枢活性的，能快速解离的多巴胺 D₂ 受体拮抗剂，对多巴胺 D_2L 受体的亲和力适中 (K_i =158 nM)，具有研究精神分裂症和躁郁症的潜力。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Dopamine Receptor

In Vivo: JNJ-37822681 (0.0025-40 mg/kg; i.h.; once) blocks D₂ receptors in rat brain at relatively low doses with an ED₅₀ value of 0.39 mg/kg and has effective in animal models of psychosis.
JNJ-37822681 (0.01-2.5 mg/kg; i.h.; once) induces minimal prolactin release at the lowest doses required for central D₂ receptor blockade.

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