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- 2025年12月05日
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- 英文名：
CHMFL-ABL-KIT-155
- 库存：
货期：询盘
- 供应商：
MedChemExpress LLC
- 规格：
询盘
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CHMFL-ABL/KIT-155
CAS No. : 2081093-21-0
MCE 国际站：CHMFL-ABL/KIT-155
产品活性：CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) 是一种高效的，具有口服活性的 type II ABL/c-KIT 双激酶抑制剂 (IC50 分别为 46 nM 和 75 nM)，对 BLK (IC50=81 nM), CSF1R (IC50=227 nM), DDR1 (IC50=116 nM), DDR2 (IC50=325 nM), LCK (IC50=12 nM), PDGFRβ (IC50=80 nM) 激酶也具有明显的抑制活性。CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) 阻止细胞周期进展和诱导细胞凋亡。
研究领域：Protein Tyrosine Kinase/RTK | Apoptosis
作用靶点：Bcr-Abl | c-Kit | Apoptosis | PDGFR | Discoidin Domain Receptor
In Vitro: CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) exhibits anti-proliferation activities in the BCR-ABL dependent CML cancer cell lines such as K562 (GI50: 0.027 µM), MEG-01 (GI50: 0.02 µM), and KU812 (GI50: 0.056 µM). It also potently inhibits the growth of c-KIT dependent GISTs cancer cell lines including GIST-T1 (GI50: 0.023 µM), GIST-882 (GI50: 0.095 µM) but not c-KIT independent GIST-48B (GI50: 3.96 µM) .
In Vivo: CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) (25-100 mg/kg; p.o.; once daily for 28 days) shows dose-dependent tumor progression suppression without apparent toxicity in female nu/nu mice bearing established K562 tumor xenografts.
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文献和实验coactivator) (22) AAAGACUCCUUAGGACCGCUU Ishikawa Apaf-1 (31) 978-998 AATTGGTGCACTTTTACGTGA IMR90E1 ARC21 (1) AF006086 181-203 aagaatgaagctgataggacc Human HeLa ATR interacting protein (4) AF451323 254-274 AAGGTCCACAGATTATTAGAT Human HeLa ATR interacting
Plant DNA methylation analysis by bisulfite genomic sequencing
and Wassenegger (2000). Back to top Procedure Preparation of Plant Genomic DNA Prepare plant genomic DNA using a Qiagen DNeasy Plant Maxi or Mini kit (see comment 1). Prior to the bisulfite-treatment, the plant genomic DNA is cleaved
AAGCAGAGUUCAAAAGCCCUU TonB, K562, hematopoetic cells View, Order View Brc-abl (32) AAAGCAGAGUUCAAAAGCCCU TonB, K562, hematopoetic cells View, Order View beta-tubulin- mouse neuronal (21) AF312873 AAGACAGAGCCAAGUGGACUC
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