重组人PEDF优惠促销

特别提示：包括重组人PEDF在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人PEDF
英文名称：Recombinant Human Pigment Epithelium-derived Factor
产品货号：GS4375
产品规格：5μg

分子量：Approximately 44.4 KDa,a single non-glycosylated polypeptide chain containing 399 amino acids.
储存条件：冷冻（-20℃）

概述

Pigment epithelium-derived factor(PEDF)is encoded by the SERPINF1 gene in humans and found in verebrates.It is a secreted phosphoglycoprotein that belongs to the clade F subfamily,serpin superfamily of proteinase inhibitors.The PEDF is a noninhibitory serpin with neurotrophic,anti-angiogenic,and anti-tumorigenic properties.It is synthesized as a 418 a.a.about 50kDaprecursor that contains a 19 a.a.signal sequence and a 399 a.a.mature region that shows a pyroglutamate at Gln20.Like other serpins,it contains three β-sheets,810 α-helices,and a C-terminal RCL(reactive center loop).Unlike other serpins with Ser protease inhibiting activity.PEDF has functions of inducing extensive neuronal differentiation in retinoblastoma cells,inhibiting of angiogenesis.As it does not undergo the S(stressed)to R(relaxed)conformational transition characteristic of active serpins,it exhibits no serine protease inhibitory activity.PEDF is researched as a therapeutic candidate for treatment of such conditions as choroidal neovascularization,heart disease,and cancer.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by its ability to enhance the adhesion of human Saos2 cells to bovine Collagen I coated plate is less than 2ng/ml,corresponding to a specific activity of>5.0×105 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in 20mMPB,pH 7.4,150 mM NaCl.
内毒素	Less than 1 EU/μg of rHuPEDF as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	QNPASPPEEG SPDPDSTGAL VEEEDPFFKV PVNKLAAAVS NFGYDLYRVR SSTSPTTNVL LSPLSVATAL SALSLGAEQR TESIIHRALY YDLISSPDIH GTYKELLDTV TAPQKNLKSA SRIVFEKKLR IKSSFVAPLE KSYGTRPRVL TGNPRLDLQE INNWVQAQMK GKLARSTKEI PDEISILLLG VAHFKGQWVT KFDSRKTSLE DFYLDEERTV RVPMMSDPKA VL

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