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- jlcR2709
- 国内
- 2025年07月15日
- WB,ELISA等
- 人/动物/植物
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
147
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
CD150/SLAM
- 抗体名：
信号淋巴细胞活化分子CD150抗体
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ¥880.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ¥1580.0 |
| 规格： | 200ul | 产品价格： | ¥2480.0 |
产品货号 : jlcR2709
英文名称 : CD150/SLAM
中文名称 : 信号淋巴细胞活化分子CD150抗体
别 名 : CD150 antigen; Cdw150; SLAM / CD150; Estm51; Ipo 3; Ipo3; MGC151472; MGC151476; Signaling lymphocytic activation molecule; Signaling lymphocytic activation molecule family member 1; Signaling lymphocytic activation molecule precursor; Slaf1; SLAM family, member 1; Slamf; Slamf1; SLAMF1 protein.
研究领域 : 免疫学
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 70kDa
细胞定位 : 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human CD150:231-335/335 <Cytoplasmic>
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : SLAM, a novel glycoprotein of 37kDa, designated SLAM (Signaling Lymphocyte Activation Molecule) or CDw150, belongs to the immunoglobulin gene superfamily and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form of SLAM and the soluble and cytoplasmic isoforms of SLAM, and the expression levels of membrane bound SLAM on B cells are rapidly regulated after activation in vitro. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells.
Function:
High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
Subunit:
nteracts (via cytoplasmic domain) with SH2D1A, and withPTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus Hprotein and acts as a receptor for this virus.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells.
Tissue Specificity:
Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.
Post-translational modifications:
Phosphorylated by FYN.
Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
Q13291
Gene ID:
6504
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD150（SLAM）为70kD的表面糖蛋白属于免疫球蛋白基因超家族。SLAM有直接诱导CD4阳性T细胞克隆与活化前T细胞的作用。CD150抗原还可以增强抗原特异性增生与通过T细胞携带的CD4抗原产生细胞因子，特别是对干扰素-γ具有极强的上调节作用。SLAM与自身配体具有极高亲和性，由SLAM同源亲和细胞间的相互作用能够刺激T淋巴细胞产生自身因子。CD150抗原还是风疹病毒细胞受体并且通过白介素10下调节。
英文名称 : CD150/SLAM
中文名称 : 信号淋巴细胞活化分子CD150抗体
别 名 : CD150 antigen; Cdw150; SLAM / CD150; Estm51; Ipo 3; Ipo3; MGC151472; MGC151476; Signaling lymphocytic activation molecule; Signaling lymphocytic activation molecule family member 1; Signaling lymphocytic activation molecule precursor; Slaf1; SLAM family, member 1; Slamf; Slamf1; SLAMF1 protein.
研究领域 : 免疫学
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 70kDa
细胞定位 : 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human CD150:231-335/335 <Cytoplasmic>
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : SLAM, a novel glycoprotein of 37kDa, designated SLAM (Signaling Lymphocyte Activation Molecule) or CDw150, belongs to the immunoglobulin gene superfamily and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form of SLAM and the soluble and cytoplasmic isoforms of SLAM, and the expression levels of membrane bound SLAM on B cells are rapidly regulated after activation in vitro. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells.
Function:
High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
Subunit:
nteracts (via cytoplasmic domain) with SH2D1A, and withPTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus Hprotein and acts as a receptor for this virus.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells.
Tissue Specificity:
Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.
Post-translational modifications:
Phosphorylated by FYN.
Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
Q13291
Gene ID:
6504
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD150（SLAM）为70kD的表面糖蛋白属于免疫球蛋白基因超家族。SLAM有直接诱导CD4阳性T细胞克隆与活化前T细胞的作用。CD150抗原还可以增强抗原特异性增生与通过T细胞携带的CD4抗原产生细胞因子，特别是对干扰素-γ具有极强的上调节作用。SLAM与自身配体具有极高亲和性，由SLAM同源亲和细胞间的相互作用能够刺激T淋巴细胞产生自身因子。CD150抗原还是风疹病毒细胞受体并且通过白介素10下调节。
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文献和实验相关实验
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CD45 由一类结构相似、分子量较大的跨膜蛋白组成，广泛存在于白细胞表面。CD45 分子在所有白细胞上都有表达，是细胞膜上信号传导的关键分子，在淋巴细胞的发育成熟，功能调节及信号传递中具有重要意义，其分布可作为某些 T 细胞亚群的分类标志。 图一：CD45/SSC-H与FSC-H/SSC-H分群对比 ❖ 如左图所示，通过 CD45 与 SSC-H，可以非常快速地圈出淋巴细胞亚群。 ❖ 如右图所示，使用 FSC-H 与 SSC-H 确定细胞群分布时，如果不染 CD45，加上有时红细胞
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信号淋巴细胞活化分子CD150抗体
¥880 - 2480
