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- PVTB00252-2a
- 2025年07月16日
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- 保存条件：
负20摄氏度
- 保质期：
3个月
- 英文名：
pFastBac TM1 Signal-IKK beta
- 库存：
100
- 供应商：
LSMBIO
- 规格：
2ug
pFastBac TM1 Signal-IKK beta Plasmid
Catalog No. PVTB00252-2a
Vector Backbone pFastBac?1 Signal
Backbone manufacturer Invitrogen
Vector type Insect Expression
Backbone size w/o insert 4775bp
Cloning site 5 Xba I
Site destroyed during cloning NO
Cloning site 3 Kpn I
Bacterial resistance Ampicillin
Growth strain DH5alpha
Growth temperature 37 Centigrade
High or low copy High Copy
Selectable markers Gentamicin
Background Insect Expression vector of Homo sapiens inhibitor of nuclear factor kappa B kinase subunit beta with C terminal 6xHis tag
Gene Information
Alternative Gene Name IKK2; IKKB; IMD15; NFKBIKB; IKBKB
Insert Gene name IKK-beta
Insert size 2271bp
Accessions AF080158
Tag His(C-term)
Species Homo sapiens (human)
Gene ID 3551
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文献和实验Use of RNA Interference to Investigate Cytokine Signal Transduction in Pancreatic Beta Cells
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by immune infiltration of the pancreatic islets resulting in an inflammatory reaction named insulitis and subsequent beta cell apoptosis. During the course of insulitis beta
Tissue-Specific Ablation of Tsc1 in Pancreatic Beta-Cells
due to mTOR-mediated enhancement of β-cell size and insulin production, but not β-cell number consistent with an important anabolic role for mTOR in β-cell function. Thus, mTOR promulgates a dominant signal to promote β-cell/islet size and insulin production
.But numerious experiments demonstrated that beta-actin expression is not constant as its previously described，such as under the circumistance of cell starvation and growth signal stimulation，beta-actin expression is either upregulated or downregulated
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