BTK| Human Tyrosine-protein ki

Protein Tyrosine Kinase and Phosphatase Expression Profiling in Human Cancers

Alterations of protein tyrosine kinase and tyrosine phosphatase are often associated with uncontrolled cell growth and cellular transformation. Because of the large number of tyrosine kinase/phosphatase genes in such gene family, it is essential

Tyrosine Kinase Inhibitors Against EGF Receptor-Positive Malignancies

epidermal growth factor receptor (EGFR) (1 –6 ), Janus kinases (JAKs) (7 –13 ), Bruton’s tyrosine kinase (BTK) (14 –16 ), platelet-derived growth factor (PDGF) (17 ), protein kinase C (PKC) (18 –24 ), Lck (25 , 26 ), Trk (27 –30

蛋白激酶A (protein kinase A，PKA)

又称依赖于cAMP的蛋白激酶A (cyclic-AMP dependent protein kinase A)，是一种结构最简单、生化特性最清楚的蛋白激酶。 PKA全酶分子是由四个亚基组成的四聚体, 其中两个是调节亚基(regulatory subunit, 简称R 亚基)，另两个是催化亚基(catalytic subunit, 简称 C 亚基)。R亚基的相对分子质量为49～55kDa, C亚基的相对分子质量为40kDa,总相对分子质量约为180kDa；全酶没有