- ￥2260
- LSM Bio
- 进口
- PAab09606
- 2025年07月17日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
zinc finger CCCH-type, antiviral 1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
O95498
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
zinc finger CCCH-type, antiviral 1
- 抗体英文名：
anti-ZC3HAV1 antibody,ZC3HAV1 antibody
- 抗体名：
anti-ZC3HAV1 抗体,ZC3HAV1 抗体
- 规格：
100μl
ZC3HAV1抗体| ZC3HAV1 antibody
货号 PAab09606
蛋白别名 DKFZp686F2052 antibody, DKFZp686H1869 antibody, DKFZp686O19171 antibody, FLB6421 antibody, FLJ13288 antibody, ZAP antibody, ZC3H2 antibody, ZC3HAV1 antibody, ZC3HDC2 antibody, Zinc finger antiviral protein
蛋白介绍
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
产品描述
anti-ZC3HAV1 antibody is a Rabbit Polyclonal antibody againstZC3HAV1..
建议稀释比例
WB:1:1000-1:10000;IHC:1:20-1:200;IP:1:1000-1:10000
IHC
Immunohistochemistry of paraffin-embedded human testis tissue slide using PAab09606( ZC3HAV1 Antibody) at dilution of 1:50
Western blot
HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab09606( ZC3HAV1 Antibody) at dilution of 1:4000(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验
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