- ￥2260
- LSM Bio
- 进口
- PAab09559
- 2025年07月17日
- ELISA,IHC,FC,IF,IP,WB
- E. coli - derived recombinant protein
- Human, Mouse ,Zebrafish
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Yes-associated protein 1, 65kDa
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse ,Zebrafish
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
O95498
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,IHC,FC,IF,IP,WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
Yes-associated protein 1, 65kDa
- 抗体英文名：
anti-YAP1 antibody,YAP1 antibody
- 抗体名：
anti-YAP1 抗体,YAP1 抗体
- 规格：
100μl
YAP1抗体| YAP1 antibody
货号 PAab09559
蛋白别名 65 kDa Yes associated protein antibody, YAP antibody, YAP1 antibody, YAP2 antibody, YAP65 antibody, YKI antibody, Yorkie homolog
蛋白介绍
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750). Isoform 2: Isoform 2 and isoform 3 can activate the C- terminal fragment (CTF) of ERBB4 (isoform 3).
产品描述
anti-YAP1 antibody is a Rabbit Polyclonal antibody againstYAP1..
建议稀释比例
WB:1:500-1:5000;IHC:1:50-1:200;IF:1:20-1:200;IP:1:200-1:2000
IHC
Immunohistochemistry of paraffin-embedded human ovary tumor using PAab09559(YAP1 antibody) at dilution of 1:100
Western blot
HeLa cells were subjected to SDS PAGE followed by western blot with PAab09559( YAP1 Antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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