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- 文献和实验
- 技术资料
- 免疫原:
UL16 binding protein 2
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
Q9BZJ3
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
UL16 binding protein 2
- 抗体英文名:
anti-ULBP2 antibody,ULBP2 antibody
- 抗体名:
anti-ULBP2 抗体,ULBP2 抗体
- 规格:
100μl
ULBP2抗体| ULBP2 antibody
货号 PAab09250
蛋白别名 ALCAN alpha antibody, N2DL 2 antibody, N2DL2 antibody, NKG2D ligand 2 antibody, NKG2DL2 antibody, RAET1H antibody, UL16 binding protein 2 antibody, ULBP2
蛋白介绍
Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
产品描述
anti-ULBP2 antibody is a Rabbit Polyclonal antibody againstULBP2..
建议稀释比例
WB : 1:500-1:5000
IHC
Western blot
Jurkat cells were subjected to SDS PAGE followed by western blot with PAab09250(ULBP2 antibody) at dilution of 1:400(本抗体仅供体外科研用途,不可用于临床诊断!) "">
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文献和实验ATPase作为胞浆和细胞膜内参,验证组分分离干净,无交叉污染。检测目标蛋白CTLA-4只存在于细胞膜组分中而不存在于细胞浆中,明确了其亚细胞定位。 膜蛋白转运研究 当研究目标蛋白是否在某些条件下或某种处理之后,会发生蛋白转运改变,可进行细胞组分分离,分别使用不同组分进行目标蛋白的检测,可以追踪蛋白转运过程的每一个环节,让文章的故事情节更完整。如下案例: 图片来源:doi:org/ 10.4049/jimmunol.1400817 Leung等人[3]研究PRL3对ULBP2
activation: C1QR1, IL31RA, INHA, INHBA, TLR1, TLR4, TLR6. Neutrophil activation: APOA2, IL8, PREX1, PRG3. Natural killer cell activation: CD2, IFNB1, IFNK, IL12B, IL2, IL21R, KIR3DL1, ULBP1, ULBP2, ULBP3. Others: AZU1, CX3CL1, ITIH1, TOLLIP
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