- ￥2260
- LSM Bio
- 进口
- PAab09028
- 2025年07月16日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
transient receptor potential cation channel, subfamily V, member 4
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
transient receptor potential cation channel, subfamily V, member 4
- 抗体英文名：
anti-TRPV4 antibody,TRPV4 antibody
- 抗体名：
anti-TRPV4 抗体,TRPV4 抗体
- 规格：
100μl
TRPV4抗体| TRPV4 antibody
货号 PAab09028
蛋白别名 Osm 9 like TRP channel 4 antibody, OTRPC4 antibody, TRP12 antibody, TRPV4 antibody, VR OAC antibody, VRL 2 antibody, VRL2 antibody, VROAC
蛋白介绍
Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040). Also activated by heat, low pH, citrate and phorbol esters (PubMed:18826956, PubMed:18695040). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13- didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity).
产品描述
anti-TRPV4 antibody is a Rabbit Polyclonal antibody againstTRPV4..
建议稀释比例
WB:1:200-1:2000;IHC:1:50-1:200
IHC
Immunohistochemistry of paraffin-embedded human kidney tissue slide using PAab09028( TRPV4 Antibody) at dilution of 1:50
Western blot
SH-SY5Y cells were subjected to SDS PAGE followed by western blot with PAab09028(TRPV4 antibody) at dilution of 1:800(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验Transient receptor potential vanilloid 4 (TRPV4) was first identified in 2000 as an osmolarity sensor. Further investigations rapidly revealed this ion channel to be a polymodal receptor with additional activating or modulating stimuli
Ca2+ Imaging as a Tool to Assess TRP Channel Function in Murine Distal Nephrons
, namely, in the freshly isolated distal nephrons, with a special emphasis on the mechanosensitive TRPV4 channel and its role in tubular flow sensing.
Transient Receptor Potential Channels and Pruritus
of the skin surface temperature which has a major impact on the epidermal permeability barrier. TRPV1 has an important role in the induction of histamine-mediated pruritus in sensory neurons while TRPV4 has a role to play in histamine-independent itch
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