- ￥2260
- LSM Bio
- 进口
- PAab09023
- 2025年07月10日
- ELISA
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
transient receptor potential cation channel, subfamily M, member 8
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
transient receptor potential cation channel, subfamily M, member 8
- 抗体英文名：
anti-TRPM8 antibody,TRPM8 antibody
- 抗体名：
anti-TRPM8 抗体,TRPM8 抗体
- 规格：
100μl
TRPM8抗体| TRPM8 antibody
货号 PAab09023
蛋白别名 LTrpC 6 antibody, LTRPC6 antibody, Trp p8 antibody, TRPM8 antibody, TRPP8
蛋白介绍
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.
产品描述
anti-TRPM8 antibody is a Rabbit Polyclonal antibody againstTRPM8..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation
, the latter influential in the discovery of TRPM8, the first TRP channel shown to be responsive to cold temperatures. TRPM8, a member of the melastatin TRP channel subfamily, is a receptor for a number of cold mimetics such as menthol and icilin, and is activated
官方解读：我们如何感知温度和疼痛？这篇文章帮你看懂今年诺奖成果
了！进一步的实验表明，该基因编码了一种新的离子通道蛋白，这一新发现的辣椒素受体后来被命名为 TRPV1。当 Julius 研究这种蛋白质对热的反应能力时，他意识到他发现了一种热感受器，这种感受器在感觉疼痛的温度下被激活。TRPV1 的发现是一个重大突破，引领并解开其他温度敏感受体研究的道路。David Julius 和 Ardem Patapoutian 各自独立地使用化学物质薄荷醇来识别 TRPM8，一种被证明能被寒冷激活的受体。另外还发现了与 TRPV1 和 TRPM8 相关的离子通道，并发
Transient Receptor Potential Channels and Pruritus
and hair morphogenesis. TRPM8 and TRPA1 interfere with the induction of sensory sensations. Cutaneously expressed temperature sensors of the TRP channel family thus became an attractive target for pharmacological treatment of pruritic, inflammatory
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