- ￥2260
- LSM Bio
- 进口
- PAab08975
- 2025年07月14日
- ELISA,WB,IHC,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
tripartite motif-containing 24
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
tripartite motif-containing 24
- 抗体英文名：
anti-TRIM24 antibody,TRIM24 antibody
- 抗体名：
anti-TRIM24 抗体,TRIM24 抗体
- 规格：
100μl
TRIM24抗体| TRIM24 antibody
货号 PAab08975
蛋白别名 HTIF1 antibody, PTC6 antibody, RING finger protein 82 antibody, RNF82 antibody, TF1A antibody, TIF1 antibody, TIF1 alpha antibody, TIF1A antibody, TIF1ALPHA antibody, TRIM24 antibody, tripartite motif containing 24
蛋白介绍
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
产品描述
anti-TRIM24 antibody is a Rabbit Polyclonal antibody againstTRIM24..
建议稀释比例
WB:1:500-1:5000;IP:1:200-1:2000;IHC:1:50-1:200;IF:1:50-1:500
IHC
Immunohistochemistry of paraffin-embedded human prostate cancer using PAab08975(TRIM24 antibody) at dilution of 1:100
Western blot
HeLa cells were subjected to SDS PAGE followed by western blot with PAab08975(TRIM24 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验三句话读懂一篇 CNS：为啥有人怎么吃都不胖？背后的基因秘密找到了；拯救秃头星人的新方法
动物研究所陈帅/王宏宇课题组在 Nature Communications 杂志上发表研究论文 TRIM24 is an insulin-responsive regulator of P-bodies。 该研究发现了 TRIM24 作为调节 mRNA 稳定性的加工体（P-body）的胰岛素响应调节因子，其调控肝脏脂质代谢的新机理，为脂肪肝的防治提供了新思路和重要分子治疗靶点！ 图 9：来源 Nature Communications 10. Cell Stem Cell：揭示 I 型干扰素信号
Standardized Post‐Mortem Examination and Fixation Procedures for Mutant and Treated Mice
Khetchoumian, K., Teletin, M., Tisserand, J., Mark, M., Herquel, B., Ignat, M., Zucman‐Rossi, J., Cammas, F., Lerouge, T., Thibault, C., Metzger, D., Chambon, P., and Losson, R. 2007. Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity
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