- ￥2260
- LSM Bio
- 进口
- PAab09101
- 2025年07月12日
- ELISA,WB,IF,IHC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
tuberous sclerosis 2
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IF,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
tuberous sclerosis 2
- 抗体英文名：
anti-Tuberin-Specific antibody,Tuberin-Specific antibody
- 抗体名：
anti-Tuberin-Specific 抗体,Tuberin-Specific 抗体
- 规格：
100μl
Tuberin-Specific抗体| Tuberin-Specific antibody
货号 PAab09101
蛋白别名 FLJ43106 antibody, LAM antibody, TSC2 antibody, TSC4 antibody, Tuberin antibody, tuberous sclerosis 2 antibody, Tuberous sclerosis 2 protein
蛋白介绍
TSC2, also named as TSC4, FLJ43106 and LAM, acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In complex with TSC1, TSC2 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. TSC2 implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. TSC2 stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. The antibody is specific to TSC2.
产品描述
anti-Tuberin-Specific antibody is a Rabbit Polyclonal antibody againstTuberin-Specific..
建议稀释比例
WB:1:200-1:2000;IHC:1:20-1:200；IF:1:10-1:100
IHC
Immunohistochemistry of paraffin-embedded human kidney slide using PAab09101( TSC2-Specific Antibody) at dilution of 1:50
Western blot
mouse lung tissue were subjected to SDS PAGE followed by western blot with PAab09101(TSC2-Specific antibody) at dilution of 1:300(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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