sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
亚型:
IgG
形态:
liquid
保存条件:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
克隆性:
单克隆
适应物种:
Human, Mouse ,Rat
保质期:
12 month
库存:
50
供应商:
LSM bio
宿主:
Rabbit
应用范围:
ELISA,WB,IHC
浓度:
≥95% as determined by SDS-PAGE
抗体英文名:
anti-SIRT6 antibody,SIRT6 antibody
抗体名:
anti-SIRT6 抗体,SIRT6 抗体
规格:
100μg
SIRT6抗体| SIRT6 antibody
货号 PAab07884
蛋白别名 SIR2L6
蛋白介绍
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
产品描述
anti-SIRT6 antibody is a Rabbit Polyclonal antibody againstSIRT6..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human brain using PAab07884(SIRT6 antibody) at dilution of 1:50
Western blot
human brain tissue were subjected to SDS PAGE followed by western blot with PAab07884(SIRT6 antibody) at dilution of 1:400(本抗体仅供体外科研用途,不可用于临床诊断!)