- ￥2262
- LSM Bio
- 进口
- PAab07884
- 2025年07月16日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human, Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
- 抗体英文名：
anti-SIRT6 antibody,SIRT6 antibody
- 抗体名：
anti-SIRT6 抗体,SIRT6 抗体
- 规格：
100μg
SIRT6抗体| SIRT6 antibody
货号 PAab07884
蛋白别名 SIR2L6
蛋白介绍
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
产品描述
anti-SIRT6 antibody is a Rabbit Polyclonal antibody againstSIRT6..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human brain using PAab07884(SIRT6 antibody) at dilution of 1:50
Western blot
human brain tissue were subjected to SDS PAGE followed by western blot with PAab07884(SIRT6 antibody) at dilution of 1:400(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验检验技士辅导:SIRT6酶延缓细胞衰老 美国斯坦福大学的研究小组最近发现，去乙酰化酶sirtuin家族成员之一SIRT6可能对延缓衰老起关键作用，以前人们一直认为，只有其“亲属”SIRT1才与衰老有关。研究人员还首次证明sirtuin能调控基因活动。该研究发表在最新一期的《细胞》杂志上。 研究小组发现，失去SIRT6的老鼠刚开始几周内能正常生长，但之后会很快衰老，并在几个月后死于低血糖。 该研究小组曾在去年证明
一箭双雕的「潜力股」，曹丰团队 Circ Res 报道它既可广谱抗癌，又能缓解阿霉素心脏毒性
The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a 的研究性论文，揭示 CircITCH 通过上调 SIRT6，Survivin，SERCA2a，使 miR-330-5p 海绵化，改善阿霉素诱导的心脏毒性。图片来源
三句话读懂一篇 CNS：老年血液会让年轻个体未老先衰？不抽烟不喝酒可大幅延长预期寿命
Journal 杂志发表研究论文 Exerkine fibronectin type-III domain-containing protein 5/irisin-enriched extracellular vesicles delay vascular ageing by increasing SIRT6 stability。 该研究发现富含 FNDC5/irisin 的 EV 有助于运动诱导的血管老化保护，表明运动因子 FNDC5/irisin 可能是与衰老相关的血管合并症的潜在靶点。图 10
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