- ￥2650
- LSM Bio
- 进口
- PAab06122
- 2025年07月13日
- ELISA,WB,IHC,IF
- E. coli - derived recombinant protein
- Human
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
p21 protein (Cdc42/Rac)-activated kinase 2
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
p21 protein (Cdc42/Rac)-activated kinase 2
- 抗体英文名：
anti-PAK2 antibody,PAK2 antibody
- 抗体名：
anti-PAK2 抗体,PAK2 抗体
- 规格：
100μl
PAK2抗体| PAK2 antibody
货号 PAab06122
蛋白别名
蛋白介绍
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF- induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase- activated PAK2 phosphorylates MKNK1 and reduces cellular translation.
产品描述
anti-PAK2 antibody is a Rabbit Polyclonal antibody againstPAK2..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human ovary using PAab06122(PAK2 antibody) at dilution of 1:100
Western blot
human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with PAab06122(PAK2 antibody) at dilution of 1:300(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
<""> <""> <""> <""> <""> <"">风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验，核纤层蛋白作为底物被caspase在一个近中部的固定部位所裂解，从而使核纤层蛋白崩解，导致靶细胞发生染色质固缩。 3．使调节蛋白丧失功能Caspase可作用于几种与细胞骨架调节有关的酶或蛋白，改变细胞结构。其中包括凝胶原蛋白(gelson)、黏着斑激酶(focaladhesionkinase，FAK)、p21活化激酶2(PAK2)等。这些蛋白的裂解导致其活性下调。如caspase可裂解凝胶原蛋白而产生片段，使之不能通过肌动蛋白纤维来调节细胞骨架。 除此以外，Caspase还能灭活或下调
技术资料暂无技术资料 索取技术资料
