- ￥2262
- LSM Bio
- 进口
- PAab05645
- 2025年07月11日
- ELISA,WB,IHC,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat, Monkey
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
neural precursor cell expressed, developmentally down-regulated 4
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat, Monkey
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
neural precursor cell expressed, developmentally down-regulated 4
- 抗体英文名：
anti-NEDD4 antibody,NEDD4 antibody
- 抗体名：
anti-NEDD4 抗体,NEDD4 抗体
- 规格：
100μl
NEDD4抗体| NEDD4 antibody
货号 PAab05645
蛋白别名 KIAA0093 antibody, NEDD4-1
蛋白介绍
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).
产品描述
anti-NEDD4 antibody is a Rabbit Polyclonal antibody againstNEDD4..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human liver tissue slide using PAab05645( NEDD4 Antibody) at dilution of 1:50
Western blot
C6 cells were subjected to SDS PAGE followed by western blot with PAab05645(NEDD4 antibody) at dilution of 1:300(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验【求助】急需Src siRNA干扰Src过程以及Src与NEDD4-1在胶质瘤信号转导方面的相关图片，谢谢
zhang666fengg 急需Src siRNA干扰Src过程以及Src与NEDD4-1在胶质瘤信号转导方面的相关图片，谢谢 doctormy Src siRNA干扰过程： Small interfering siRNA duplexes for Src was obtained from Dharmacon (Lafayette, CO). A scrambled sequence was used
三句话读懂一篇 CNS！首次提取超 100 万年的 DNA；轻轻一喷，瞬时改变作物性状...
。 值得一提的是，该重组载体对环境没有潜在威胁，只要轻轻一喷，植物开花时间、春化、株型以及抗旱性在内的等多种关键性状即可受到控制！ 图片来源：Nature Plants 7. Nature Communications：揭示泛素化调节抗病毒免疫反应 泛素化是最普遍的蛋白质翻译后修饰之一，在多种细胞和生物学过程中起着重要作用。 2021 年 2 月 19 日，海军军医大学安华章及袁红斌共同通讯在 Nature Communications 发表论文 E3 ligase Nedd4l promotes
regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the IGF-1 response. PMID: 23195959 本文由丁香园论坛提供，想了解更多有用的、有意思的前沿资讯以及酷炫的实验方法的你，都可以成为师兄的好伙伴 师兄微信号：shixiongcoming
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