- ￥2262
- LSM Bio
- 进口
- PAab03924
- 2025年07月12日
- ELISA,WB,IHC,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 免疫原：
high-mobility group box 1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P15248
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
high-mobility group box 1
- 抗体英文名：
anti-HMGB1 antibody,HMGB1 antibody
- 抗体名：
anti-HMGB1 抗体,HMGB1 抗体
- 规格：
100μg
HMGB1抗体| HMGB1 antibody
货号 PAab03924
蛋白别名 DKFZp686A04236 antibody, high mobility group box 1 antibody, High mobility group protein 1 antibody, High mobility group protein B1 antibody, HMG 1 antibody, HMG1 antibody, HMG3 antibody, HMGB1 antibody, SBP 1
蛋白介绍
The HMG (high mobility group) proteins are nonhistone chromosomal proteins that is present in almost all eukaryotic cells, and it functions to stabilize NUCLEOSOME formation and acts as a transcription-factor-like protein that regulates the expression of several genes[PMID: 18160415]. Once injury, infection or other inflammatory stimuli, activated macrophages, mature dendritic cells and natural killer cells can secret HMGB1, which act as a crucial cytokine[PMID: 20163887]. HMGB1 also involved in V(D)J recombination by acting as a cofactor of the RAG complex, stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS)[PMID: 19360789 ]. Act as a Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. HMGB1 (high mobility group box 1) modulates gene expression in the nucleus, but certain immune cells secrete HMGB1 as an extracellular Alarmin to signal tissue damage.The nuclear HMGB1 relocalizes to the extracellular milieu in senescent human and mouse cells in culture and in vivo, which stimulated cytokine secretion through TLR-4 signaling (23649808).This antibody is a rabbit polyclonal antibody raised against full length HMGB1 of human origin.
产品描述
anti-HMGB1 antibody is a Rabbit Polyclonal antibody againstHMGB1..
建议稀释比例
WB:1:500-1:5000;IP:1:200-1:2000;IHC:1:50-1:200
IHC
Immunohistochemistry of paraffin-embedded human breast cancer using PAab03924(HMGB1 antibody) at dilution of 1:100
Western blot
Jurkat cells were subjected to SDS PAGE followed by western blot with PAab03924(HMGB1 antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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- 作者
- 内容
- 询问日期
文献和实验Fluorescent Biosensors for the Detection of HMGB1 Release
During necrosis and following some instances of apoptosis (in particular in the absence of a proficient phagocytic system), the nonhistone chromatin component high-mobility group box 1 (HMGB1) is released in the extracellular space. In vivo
因为journal club要讲文章 顺便儿拿来和大家讨论下 Hmgb1调节TLR4介导的angiogenesis 最近才开始关注这个蛋白。这篇文章已经在线发表在atvb上，由中山医眼科中心完成的工作。 Hmgb1不仅可以作为一种nuclear factor, 而且还可以作为cytokine来介导感染引起的炎症，免疫损伤。Hmgb1已经在sepsis, arthritis, 肿瘤和其他多种疾病中明确了其作用。Hmgb1可以结合tlr2/4，并且通过MyD88依赖性信号通路促进
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 人高迁移率族蛋白-1 ( HMGB1 )ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 HMGB1 单抗包被于酶标板上，标准品和样品中的 HMGB1与单抗结合，加入生物
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