- ￥2262
- LSM Bio
- 进口
- PAab03201
- 2025年07月17日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
forkhead box O1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
FOXO1
- 抗体英文名：
anti-FOXO1 antibody,FOXO1 antibody
- 抗体名：
anti-FOXO1 抗体,FOXO1 抗体
- 规格：
100μl
FOXO1抗体| FOXO1 antibody
货号 PAab03201
蛋白别名 FKHR antibody, FOXO1A
蛋白介绍
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide- damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
产品描述
anti-FOXO1 antibody is a Rabbit Polyclonal antibody againstFOXO1..
建议稀释比例
WB:1:200-1:2000;IHC:1:20-1:200
IHC
Immunohistochemistry of paraffin-embedded mouse brain tissue slide using PAab03201( FOXO1 Antibody) at dilution of 1:200
Western blot
HeLa cells were subjected to SDS PAGE followed by western blot with PAab03201( FOXO1 Antibody) at dilution of 1:600(本抗体仅供体外科研用途，不可用于临床诊断!)
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