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- 详细信息
- 文献和实验
- 技术资料
- 库存:
999
- 供应商:
北京索莱宝科技有限公司
- 检测范围:
1-2200 pg/ml
- 检测方法:
Sandwich ELISA
- 应用:
ELISA
- 适应物种:
Canine
- 标记物:
none
- 样本:
血清/血浆/细胞培养上清
- 规格:
48T/96T
| 规格: | 48T | 产品价格: | ¥2000.0 |
|---|---|---|---|
| 规格: | 96T | 产品价格: | ¥3200.0 |
TNF-α, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II
membrane protein . Membrane bound TNF-α is cleaved by the metalloprotease TACE/ADAM17 to
generate a soluble homotrimer . Both membrane and soluble forms of TNF-α are biologically active. TNF-α is produced primarily by macrophages, but it is produced also by a broad variety of cell types
including lymphoid cells, mast cells, endothelial cells,cardiac myocytes, adipose tissue, fibroblasts, and neuronal tissue. TNF-α plays a key regulatory role in inflammation and host defense against
bacterial infection, notably Myc obacterium tuberc ulosis. The role of TNF-α in autoimmunity is
underscored by blocking TNF-α action to treat rheumatoid arthritis and Crohn’s disease

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文献和实验1. Aggarwal, B.B. (2003) Nat Rev Immunol 3, 745-56.
2. Hehlgans, T. and Pfeffer, K. (2005) Immunology 115, 1-20.
3. Lin, P.L. et al. (2007) J Investig Dermatol Symp Proc 12, 22-5.
4. Brennan, F.M. and McInnes, I.B. (2008) J Clin Invest 118,
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