小鼠抗Akt1抗体北京现货

特别提示：包括小鼠抗Akt1抗体在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：小鼠抗Akt1抗体
英文名称：Akt1 Mouse Monoclonal Antibody
产品货号：YT679
产品规格：50μl

本品为来源于小鼠的抗Akt1的单克隆抗体
宿主：小鼠
用途：WB,FC, IHC,ICC, IF
交叉反应性：人，小鼠
分子量：56KDa
推荐稀释比例：WB(1:1000),IF(1:50-1:100),IHC(1:50-1:100),ICC(1:50-1:100),FC(1:50-1:100)
克隆性：单克隆抗体
 

About this Antibody
Name	Akt1 Mouse Monoclonal Antibody
Category	Monoclonal antibody(mAb); Primary antibody
Isotype	IgG2b
Purification	ProA affinity purified
About the Immunogen
Immunogen	This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to a region of AKT1.
Gene ID	207
SwissProt	P31749/P31751/Q9Y243
Synonyms	RAC-PK-alpha; Protein kinase B; PKB;C-AKT;RAC-PK-beta; Protein kinase Akt-2; Protein kinase B, beta; RAC-PK-gamma; Protein kinase Akt-3; Protein kinase B, gamma; STK-2
Category	PI3K / Akt Signaling
Background	The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mice lacking Akt1 display a 25% reduction in body mass, indicating that Akt1 is critical for transmitting growth-promoting signals, most likely via the igf1 receptor. Mice lacking Akt1 are also resistant to cancer: They experience considerable delay in tumor growth initiated by the large T antigen or the Neuoncogene.

注意事项：
1. 如果本抗体用于Western blot (WB)、免疫荧光(IF)、免疫细胞化学(ICC)等实验，请注意回收使用过的稀释抗体。回收的抗体通常至少可以重复使用5-10次。稀释后的抗体，包括已经使用过的稀释抗体，请4℃保存。
2. 回收后重复使用的抗体，使用方法同新鲜稀释的抗体。如果在重复使用过程中发现抗体出现轻微混浊现象，可以10,000g离心1-3分钟，取上清用于后续检测。如果回收的抗体出现明显的絮状物或长霉长菌等情况，则可以考虑废弃该抗体。
3. 提供的Western一抗稀释液也可以用于免疫荧光(IF)、免疫组化(IHC)、免疫细胞化学(ICC)等适当用途。如果希望获得最佳的检测效果，请考虑使用上述检测专用的一抗稀释液。

储存条件：-20℃，有效期一年。

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