重组人IL-36RA优惠促销

特别提示：包括重组人IL-36RA在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人IL-36RA
英文名称：Recombinant Human Interleukin-36 Receptor Antagonist Protein
产品货号：GS4537
产品规格：2μg

分子量：Approximately 16.8kDa,a single non-glycosylated polypeptide chain containing 154 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-36 receptor antagonist(IL-36RA)is a secreted protein which belongs to the interleukin 1 cytokine family(IL-1 family)and it is predominantly expressed in keratinocytes but not in fibroblasts,endothelial cells or melanocytes.IL-36RA has been reported to antagonize the biological activity of IL-36α(IL-1F6),IL-36β(IL-1F8),and IL-36γ(IL-1F9).Furthermore,it could constitute part of an independent signaling system analogous to interleukin-1 alpha(IL-1A),beta(IL-1B)receptor agonist and interleukin-1 receptor type I(IL-1R1).In addition,The receptor for IL-36RA has not been positively identified.Indirect evidence suggests it is IL-1Rrp2.Recombinant human IL-36 RA contains 154 amino acid residues and it shares 91%a.a.sequence identity with murine IL-36RA.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by inhibiting IL-36 beta induced IL-8 secretion by human preadipocytes is less than 1.0μg/ml,corresponding to a specific activity of>1000 IU/mg in the presence of 20ng/ml of recombinant human IL-36 beta.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuIL-36RA as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAGKVIKGEE ISVVPNRWLD ASLSPVILGV QGGSQCLSCG VGQEPTLTLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTVPEADQPV RLTQLPENGG WNAPITDFYF QQCD

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