重组大鼠BD-4现货供应

特别提示：包括重组大鼠BD-4在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组大鼠BD-4
英文名称：Recombinant Rat Beta-defensin 4
产品货号：GS4589
产品规格：5μg

分子量：Approximately 4.4kDa,a single non-glycosylated polypeptide chain containing 41 amino acids.
储存条件：冷冻（-20℃）

概述

Defensins(alpha and beta)are cationic peptides with antimicrobial activity against Gram-negative and Gram-positive bacteria,fungi,and enveloped viruses.They are 2-6 kDa proteins and take important roles in innate immune system.On the basis of their size and pattern of disulfide bonding,mammalian defensins are classified into alpha,beta and theta categories.β-Defensins are expressed on some leukocytes and at epithelial surfaces.They contain a six-cysteine motif that forms three intra-molecular disulfide bonds.Because β-defensins are cationic peptides,they can therefore interact with the membrane of invading microbes,which are negative due to lipopolysaccharides(LPS)and lipoteichoic acid(LTA)found in the cell membrane.Especially,they have higher affinity to the binding site compared to Ca2+ and Mg2+ ions.Furthermore,they can affect the stability of the membrane.Additionally,they are not only have the ability to strengthen the innate immune system but can also enhance the adaptive immune system by chemotaxis of monocytes,T-lymphocytes,dendritic cells and mast cells to the infection site.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The biologically active determined by a chemotaxis bioassay using human monocytes is in a concentration range of 0.1-100.0ng/ml.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in 10mMPB,pH 7.4,500 mM NaCl.
内毒素	Less than 1 EU/μg of rRtBD-4 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	QSINNPITCL TKGGVCWGPC TGGFRQIGTC GLPRVRCCKK K

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