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- 生长状态：
贴壁生长
- 年限：
43 years adult
- 运输方式：
冻存运输
- 细胞形态：
上皮样
- 器官来源：
皮肤
- 库存：
大量
- 物种来源：
人
- 是否是肿瘤细胞：
1
- 相关疾病：
黑色素瘤
- ATCC Number：
CRL-11147™
| Designations: | A2058 | ||
| Depositors: | W Stetler-Stevenson | ||
| Biosafety Level: | 1 | ||
| Shipped: | frozen | ||
| Medium & Serum: | See Propagation | ||
| Growth Properties: | adherent | ||
| Organism: | Homo sapiens | ||
| Morphology: | epithelial |
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| Source: | Organ: skin Disease: melanoma Derived from metastatic site: lymph node |
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| Permits/Forms: | In addition to the MTA mentioned above, other ATCC and/or regulatory permits may be required for the transfer of this ATCC material. Anyone purchasing ATCC material is ultimately responsible for obtaining the permits. Please click here for information regarding the specific requirements for shipment to your location. | ||
| Applications: | transfection host | ||
| Receptors: | nerve growth factor (NGF), expressed laminin, expressed |
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| Tumorigenic: | Yes | ||
| DNA Profile (STR): | Amelogenin: X,Y CSF1PO: 10,11 D13S317: 13,14 D16S539: 9,13 D5S818: 9,12 D7S820: 11 THO1: 7,9 TPOX: 8 vWA: 14,18 |
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| Age: | 43 years adult | ||
| Gender: | male | ||
| Ethnicity: | Caucasian | ||
| Comments: | This cell line is highly invasive and provides a source of cellular invasion associated proteins (such as the 72000 dalton type IV collagenase. Tissue inhibitor of metalloproteinase-2 [TIMP-2], autocrine motility factor and the 67000 dalton laminin receptor. |
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| Propagation: | ATCC complete growth medium: The base medium for this cell line is ATCC-formulated Dulbecco's Modified Eagle's Medium, Catalog No. 30-2002. To make the complete growth medium, add the following components to the base medium: fetal bovine serum to a final concentration of 10%. Atmosphere: air, 95%; carbon dioxide (CO2), 5% Temperature: 37.0°C |
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| Subculturing: | Protocol:
Subcultivation Ratio: A subcultivation ratio of 1:6 to 1:12 is recommended Medium Renewal: Every 2 to 3 days |
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| Preservation: | Freeze medium: Complete growth medium supplemented with 5% (v/v) DMSO Storage temperature: liquid nitrogen vapor phase |
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| Related Products: | Recommended medium (without the additional supplements or serum described under ATCC Medium):ATCC 30-2002 recommended serum:ATCC 30-2020 |
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| References: | 22590: Fabricant RN, et al. Nerve growth factor receptors on human melanoma cells in culture. Proc. Natl. Acad. Sci. USA 74: 565-569, 1977. PubMed: 265522 23263: Sherwin SA, et al. Human melanoma cells have both nerve growth factor and nerve growth factor-specific receptors on their cell surfaces. Proc. Natl. Acad. Sci. USA 76: 1288-1292, 1979. PubMed: 375235 23269: Todaro GJ, et al. Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors. Proc. Natl. Acad. Sci. USA 77: 5258-5262, 1980. PubMed: 6254071 23404: Stetler-Stevenson WG, et al. The activation of human type IV collagenase proenzyme. Sequence identification of the major conversion product following organomercurial activation. J. Biol. Chem. 264: 1353-1356, 1989. PubMed: 2536363 23549: Stetler-Stevenson WG, et al. Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family. J. Biol. Chem. 264: 17374-17378, 1989. PubMed: 2793861 |
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文献和实验相关实验
The Activity of rRNA Resistance Methyltransferases Assessed by MALDI Mass Spectrometry
, and streptogramin B (MLSB ) antibiotics. The target for Erm methyltransferases is at nucleotide A2058 in 23S rRNA, and methylation occurs before the rRNA has been assembled into 50S ribosomal particles. Erm methyltransferases occur in a phylogenetically wide range
单核苷酸多态性（single nucleotide polymorphisms，SNPs）简介
signal regulated kinase,ERK），p38和c-Jun N端激酶（c-Jun N-terminal kinase,JNK）.它们都是以核转录因子家族活性蛋白－1（activated protein-1 AP-1）和ETS转录因子家族为底物的.MMP-1启动子-1607位点的2G SNP提供了一个ETS结合位点，和－1602位点的AP-1结合位点共同作用，促进MMP-1的转录，因此，2G SNP与1G SNP相比，MMP-1的转录活性提高[172，173].黑色素瘤细胞系A2058
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A2058
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