Apremilast(608141-41-9)(≥99%)

特别提示：包括Apremilast在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：Apremilast
英文名称：Apremilast
产品货号：L10036
产品规格：5mg|25mg|100mg
 

属性

CAS号	608141-41-9
分子式	C22H24N2O7S
分子量	460.5
溶解性	DMSO 92mg/mL Water<1 mg/mL Ethanol<1 mg/mL
存贮条件	储存温度-20℃

描述

产品介绍	Apremilast(CC-10004)是一种口服生物有效的PDE4和TNF-α抑制剂，IC50分别为74 nM和77 nM。
生化机理	Apremilast,a novel small mol.inhibitor of PDE4.Apremilast has profound anti-inflammatory properties in animal models of inflammatory disease,as well as human chronic inflammatory diseases such as psoriasis and psoriatic arthritis.Apremilast blocks the synthesis of several pro-inflammatory cytokines and chemokines,such as tumor necrosis factor alpha,interleukin 23,CXCL9,and CXCL10 in multiple cell types.As this novel PDE4 inhibitor interferes with several key processes of inflammation,Apremilast may emerge as a promising new drug for the treatment of chronic inflammatory diseases such as those of the skin and the joints.
别名	(S)-2-[1-(3-乙氧基-4-jiǎ氧基苯基)-2-甲磺酰基乙基]-4-乙酰基氨基异吲哚啉-1,3-二酮;CC-10004;ApreMilast;(S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide;ApreMilast,CC-10004

我公司销售的Apremilast(608141-41-9)(≥99%)，(S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione，(S)-2-[1-(3-乙氧基-4-jiǎ氧基苯基)-2-甲磺酰基乙基]-4-乙酰基氨基异吲哚啉-1,3-二酮，ApreMilast，CC-10004，(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide，ApreMilast,CC-10004质量上佳，价格普惠，欢迎广大新老客户踊跃订购。