CHDI-390576,1629729-98-1

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CHDI-390576

CAS No. : 1629729-98-1

MCE 国际站：CHDI-390576

产品活性：CHDI-390576，一种有效的细胞渗透性和中枢神经系统渗透性的 IIa 类组织乙酰酶 (HDAC) 抑制剂，IIa 类 HDAC 4、HDAC 5、HDAC 7、HDAC 9 的 IC₅₀ 值分别为 54 nM、60 nM、31 nM、50 nM，选择性高于 I 类 HDAC (1, 2, 3) 500 倍，高于 HDAC8 和 IIb 类 HDAC6 亚型约 150 倍。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：HDAC

In Vitro: The affinity (K_d) of CHDI-390576 to the catalytic domain of immobilized HDAC4 is 80 nM.
CHDI-390576 inhibits class I HDACs (1, 3, 8) and class IIb HDAC6 isoforms with IC₅₀s of 39.7μM, 25.8 μM, 9.1 μM, 6.2 μM, respectively.

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