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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
TCS JNK 6o
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
894804-07-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1650.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥700.0 |
| 规格： | 5 mg | 产品价格： | ￥1500.0 |
| 规格： | 10 mg | 产品价格： | ￥2500.0 |
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JNK Inhibitor VIII
CAS No. : 894804-07-0
MCE 国际站：JNK Inhibitor VIII
产品活性：JNK Inhibitor VIII (TCS JNK 6o) 是 c-Jun N-末端激酶 (JNK-1, -2, -3) 抑制剂，抑制 JNK-1、JNK-2、JNK-3 的 Ki 值分别为 2 nM、4 nM、52 nM，对 JNK-1、JNK-2 的 IC50 值分别是 45 nM 和 160 nM。
研究领域：MAPK/ERK Pathway
作用靶点：JNK
In Vitro: JNK Inhibitor VIII (TCS JNK 6o) 对 JNK-1 和-2 的选择性超过其他 MAP 激酶，包括 ERK2、p38α 和 p38δ。
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文献和实验dream_reloaded A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold
. Similar biphasic pattern of JNK activation is also observed in the parental PC12 cells. Using the specific JNK inhibitor SP600125, we show that the biphasic activation is necessary for neurite outgrowth and branching, and that inhibition
Cortical Neurons Culture to Study c-Jun N-Terminal Kinase Signaling Pathway
. As an example we describe the use of the cell permeable specific JNK inhibitor peptide as a neuroprotective agent. This chapter will give methodological suggestions to help researchers prepare
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