重组人sTNF RI/TNFRSF1A北京品牌

特别提示：包括重组人sTNF RI/TNFRSF1A在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人sTNF RI/TNFRSF1A
英文名称：Recombinant Human soluble Tumor Necrosis Factor Receptor Type I/TNFRSF1A (rHusTNF RI/TNFRSF1A)
产品货号：GS4919
产品规格：5μg

分子量：Approximately 21.2kDa,a single non-glycosylated polypeptide chain containing 190 amino acids.
储存条件：冷冻（-20℃）

概述

TNF RI,also named as TNFR-I,TNF R1,TNFRSF1A,p55 and p60,belongs to the tumor necrosis factor receptor superfamily,and it is encoded by the TNFRSF1A gene in human.TNF RI is a universally expressed protein and is thought to form homotrimers after ligand binding.TNF RI is one of the major receptors for the TNF-α.This receptor can activate the transcription factor NF-κB,mediate apoptosis,and function as a regulator of inflammation.Mature human soluble TNF RI shares 68%~73%amino acid sequence identity with murine,rat,bovine and porcine soluble TNF RI.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 cells is less than 0.05μg/ml,corresponding to a specific activity of>2×104IU/mg in the presence of 0.25ng/mL of rHuTNF-alpha.
成分	Lyophilized from a 0.2μmfiltered solution in PBS,pH 7.4.
内毒素	Lyophilized from a 0.2μmfiltered solution in PBS,pH 7.4.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	IYPSGVIGLV PHLGDREKRD SVCPQGKYIH PQNNSICCTK CHKGTYLYND CPGPGQDTDC RECESGSFTA SENHLRHCLS CSKCRKEMGQ VEISSCTVDR DTVCGCRKNQ YRHYWSENLF QCFNCSLCLN GTVHLSCQEK QNTVCTCHAG FFLRENECVS CSNCKKSLEC TKLCLPQIEN VKGTEDSGTT

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