重组人IL-36β(153a.a.)北京品牌

特别提示：包括重组人IL-36β(153a.a.)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人IL-36β(153a.a.)
英文名称：Recombinant Human Interleukin-36 beta, 153a.a.
产品货号：GS4659
产品规格：2μg

分子量：Approximately 17.2kDa,a single non-glycosylated polypeptide chain containing 153 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36 beta is reported to be expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin and it can stimulate production of interleukin-6 and interleukin-8 in synovial fibrobasts,articular chondrocytes and mature adipocytes.It has two isoforms.IL-36β isoform 2 contains one potential N-linked glycosylation site in its C-terminus,while IL-36β isoform 1 lacks potential N-linked glycosylation sites and four of the conserved β-strands.Human IL-36β isoform 2 shares 62%,67%,63%and 59%a.a.identity with the most similar isoform of mouse,canine,bovine and equine IL-36β,respectively.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by inducing IL-8 secretion in human preadipocytes is less than 10ng/ml,corresponding to a specific activity of>1.0×105 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in 2×PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuIL-36β,153a.a.as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	REAAPKSYAI RDSRQMVWVL SGNSLIAAPL SRSIKPVTLH LIACRDTEFS DKEKGNMVYL GIKGKDLCLF CAEIQGKPTL QLKEKNIMDL YVEKKAQKPF LFFHNKEGST SVFQSVSYPG WFIATSTTSG QPIFLTKERG ITNNTNFYLD SVE

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