重组人IL-36α(153a.a.)北京现货

特别提示：包括重组人IL-36α(153a.a.)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人IL-36α(153a.a.)
英文名称：Recombinant Human Interleukin-36 alpha, 153a.a.
产品货号：GS4657
产品规格：2μg

分子量：Approximately 17.1kDa,a single non-glycosylated polypeptide chain containing 153 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.Studies showed IL-36α is mainly found in skin and lymphoid tissues,but also in fetal brain,trachea,stomach and intestine.Notably,IL-36 alpha is the only novel IL-1 family member expressed on T-cells.Recombinant human interleukin-36 alpha(153 a.a.)contains 153 amino acids residues which is a single non-glycosylated polypeptide and it shares 57 – 68%a.a.sequence identity with mouse,rabbit,equine and bovine IL-36α and 27 – 57%a.a.sequence identity with other novel IL-1 family members.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by inducing IL-8 secretion in human preadipocytes is less than 10ng/ml,corresponding to a specific activity of>1.0×105 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in 20mMTris,300 mM NaCl,pH 8.0,0.1%Tween 80.
内毒素	Less than 1 EU/μg of rHuIL-36α,153a.a.as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	KIDTPQQGSI QDINHRVWVL QDQTLIAVPR KDRMSPVTIA LISCRHVETL EKDRGNPIYL GLNGLNLCLM CAKVGDQPTL QLKEKDIMDL YNQPEPVKSF LFYHSQSGRN STFESVAFPG WFIAVSSEGG CPLILTQELG KANTTDFGLT MLF

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